2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 1 ·1977-07-00 ·Pages 26-30

Martel A, Moreau N, Capmau ML, Soussy CJ, Duval J

Abstract

A wild-type strain of Staphylococcus aureus that inactivates the 4,6-glycosidically linked deoxystreptamine aminoglycoside antibiotics by a plasmid-mediated process was found to harbor two enzymes: an acetyltransferase of the AAC(6') type and a new phosphotranferase specific to the gentamicin components. The target of this last enzyme is the 2''-hydroxyl function of these antibiotics, since one inactivated compound is 2''-(O)-phosphorylsisomicin.

MeSH Terms

Acetyltransferases/metabolism Aminoglycosides/pharmacology Anti-Bacterial Agents/pharmacology Chemical Phenomena Chemistry Drug Resistance, Microbial Gentamicins/metabolism Isoelectric Focusing Molecular Weight Phosphotransferases/metabolism Plasmids Staphylococcus aureus/drug effects,enzymology,metabolism

Chemicals

Aminoglycosides Anti-Bacterial Agents Gentamicins Acetyltransferases Phosphotransferases

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Martel A

Moreau N

Capmau M L

Soussy C J

Duval J

References (14)

14 references, click to expand

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Purification by affinity chromatography of an enzyme involved in gentamicin inactivation.
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Enzymatic modification of aminoglycoside antibiotics: a new 6'-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
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Properties of the gentamicin acetyltransferase enzyme and application to the assay of aminoglycoside antibiotics.
Antimicrob Agents Chemother. 1975 Aug;8(2):222-3 PMID: 1101816
[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].
Biochimie. 1974;56(6-7):893-7 PMID: 4614862
New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.
Antimicrob Agents Chemother. 1976 Aug;10(2):258-64 PMID: 984767
Gentamicin resistance in Staphylococcus aureus.
Lancet. 1976 Jan 3;1(7949):20-1 PMID: 54520
A new rapid and powerful technique to obtain purified ribosomes.
FEBS Lett. 1974 Apr 15;41(1):69-72 PMID: 4604018
Purification and properties of gentamicin acetyltransferase I.
Biochemistry. 1976 Jan 13;15(1):125-31 PMID: 764855
[ANT(4')I: a new aminoglycoside nucleotidyltransferase found in "staphylococcus aureus" (author's transl)].
Ann Microbiol (Paris). 1976 Apr;127(3):391-9 PMID: 1047990
The structure of sisomicin, a novel unsaturated aminocyclitol antibiotic from Micromonospora inyoensis.
J Org Chem. 1974 May 31;39(11):1451-7 PMID: 4833504
[Purification by affinity chromatography of an acetyltransferase and phosphotransferase inactivating aminosidic antibiotics].
Biochimie. 1973;55(10):1183-6 PMID: 4602330
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.12.1.26

Published

1977-07-00

Pages

26-30

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352148

Subset

External Links

PubMed source DOI: 10.1128/AAC.12.1.26 PMC Full Text View journal details

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2"-O-phosphorylation of gentamicin components by a Staphylococcus aureus strain carrying a plasmid.

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