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PMID: 883965 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of acetoacetate administration on glucose metabolism in mammary gland of fed lactating rats.

The Biochemical journal ·Vol. 164 ·No. 3 ·1977-06-15 ·Pages 749-52

Robinson AM, Williamson DH

Abstract

Administration of acetoactate to fed lactating rats rapidly decreases glucose uptake by the mammary gland, and causes an output of pyruvate, whereas lactate uptake remains unchanged. Similar changes, though not identical, occur in starved lactating rats, which suggests that the increased acetoacetate concentration in this situation may be one of the factors responsible for the alterations in glucose metabolism.

MeSH Terms
Acetoacetates/pharmacology Animals Female Glucose/metabolism Lactation/drug effects Mammary Glands, Animal/drug effects,metabolism Pregnancy Rats
Chemicals
Acetoacetates Glucose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Robinson A M
Williamson D H
References (10)
10 references, click to expand
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    Biochem J. 1967 Oct;105(1):225-31 PMID: 6056624
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    Biochem J. 1971 Nov;125(2):541-4 PMID: 4259412
  7. Regulation of mammalian pyruvate dehydrogenase.
    Mol Cell Biochem. 1975 Oct 31;9(1):27-53 PMID: 171557
  8. Measurements of substrate uptake by mammary gland of the rat.
    Biochem J. 1972 Oct;129(5):1171-3 PMID: 4676363
  9. Interactions of glucose, acetoacetate and insulin in mammary-gland slices of lactating rats.
    Biochem J. 1975 Aug;150(2):145-52 PMID: 1180913
  10. Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats.
    Diabetologia. 1976 May;12(2):149-54 PMID: 1269848
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1640749
Published
1977-06-15
Pages
749-52
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1164855
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1640749 PMC Full Text View journal details
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