katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.
katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing. By PCR, katG was not detected in 3 of 54 strains. Sequencing of katG from 13 strains showed small point mutations or insertions; a previously described mutation causing a Ser-to-Thr change at position 315 was found in 4 strains, and there were nine new missense mutations of katG. A 209-bp segment of inhA from 17 strains was sequenced, but no mutations were observed. This result indicates that different mutations prevail in different geographical areas.
15 references, click to expand
-
New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains.Lancet. 1995 Aug 19;346(8973):502-3 PMID: 7637495
-
Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.J Infect Dis. 1994 May;169(5):1162-5 PMID: 8169415
-
Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.J Infect Dis. 1995 Jan;171(1):240-5 PMID: 7798673
-
Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City.J Infect Dis. 1993 Oct;168(4):1063-5 PMID: 8376822
-
The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.Nature. 1992 Aug 13;358(6387):591-3 PMID: 1501713
-
Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance.J Infect Dis. 1996 Jan;173(1):196-202 PMID: 8537659
-
Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.J Infect Dis. 1995 Apr;171(4):954-60 PMID: 7706824
-
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Science. 1994 Jan 14;263(5144):227-30 PMID: 8284673
-
Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.Antimicrob Agents Chemother. 1995 Nov;39(11):2472-7 PMID: 8585728
-
Catalase expression, katG, and MIC of isoniazid for Mycobacterium tuberculosis isolates from São Paulo, Brazil.J Infect Dis. 1995 Jan;171(1):237-40 PMID: 7798672
-
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.J Bacteriol. 1993 Jul;175(13):4255-9 PMID: 8320241
-
Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis.Infect Immun. 1995 Apr;63(4):1427-33 PMID: 7890405
-
Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis.Mol Microbiol. 1995 Jan;15(2):235-45 PMID: 7746145
-
Detection and identification of mycobacteria by amplification of a segment of the gene coding for the 32-kilodalton protein.J Clin Microbiol. 1992 Aug;30(8):2025-8 PMID: 1500509
-
Isoniazid-resistance and catalase activity of tubercle bacilli; a preliminary report.Am Rev Tuberc. 1954 Mar;69(3):471-2 PMID: 13138881
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