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PMID: 888910 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Morphometric analysis of hypertension-induced hypertrophy of rat thoracic aorta.

The American journal of pathology ·Vol. 88 ·No. 3 ·1977-09-00 ·Pages 619-34

Wiener J, Loud AV, Giacomelli F, Anversa P

Abstract

The response of the intima-media of the thoracic aorta to 1 to 4 weeks of two-kidney renal hypertension in the rat has been analyzed by morphometric techniques at light and electron microscopic levels. The increased thickness of the aorta that ensues is the result of an increase in the size but not the number of smooth muscle cell layers. The volume fractions of intima occupied by endothelium (26%), internal elastic lamina (37%), and subendothelial space (37%) in normotensive animals are not significantly altered by the hypertension. The percent increases in muscle cross-sectional area is greatest (58 to 60%) in the two innermost layers (M1 and M2). M1 is composed of nearly equal compartments of smooth muscle cells and interstitial space that expand 69% and 50%, respectively, with hypertension. Analysis of the subcellular constituents of the M1 smooth muscle cells indicates that significant changes in absolute volume include increases of caveolae (45%), myofibrils (59%), mitochondria (81%), glycogen (163%), and rough endoplasmic reticulum (221%). Factors contributing to these alterations are discussed.

MeSH Terms
Animals Aorta, Thoracic/chemistry,pathology Endoplasmic Reticulum/ultrastructure Endothelium/ultrastructure Glycogen/analysis Hypertension, Renal/pathology Hypertrophy Male Mitochondria, Muscle/ultrastructure Muscle, Smooth/chemistry,pathology Myofibrils/ultrastructure Rats
Chemicals
Glycogen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wiener J
Loud A V
Giacomelli F
Anversa P
References (56)
56 references, click to expand
  1. The cellular pathology of experimental hypertension. 7. Structure and permeability of the mesenteric vasculature in angiotensin-induced hypertension.
    Am J Pathol. 1973 Aug;72(2):221-31 PMID: 4124863
  2. Arteriolar abnormalities with chronic systemic hypertension. A quantitative study.
    Circulation. 1967 Apr;35(4):662-70 PMID: 6024008
  3. Quantitative radioautographic localization of protein synthesis in experimental cardiac hypertrophy.
    Lab Invest. 1973 Sep;29(3):282-92 PMID: 4270347
  4. Myofibrillar mass in rat and rabbit heart muscle. Correlation of microchemical and stereological measurements in normal and hypertrophic hearts.
    Circ Res. 1972 Apr;30(4):430-9 PMID: 4259117
  5. A histometric study of cerebral and renal arteries in normotensives and chronic hypertensives.
    J Pathol. 1972 Oct;108(2):129-35 PMID: 4647505
  6. Arterial lysosomes and connective tissue in primate atherosclerosis and hypertension.
    Circ Res. 1975 Apr;36(4):553-61 PMID: 1116247
  7. Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.
    Proc Natl Acad Sci U S A. 1974 Aug;71(8):3019-23 PMID: 4370097
  8. Hypertension of renal origin: evidence for two different mechanisms.
    Science. 1971 Dec 24;174(4016):1344-6 PMID: 4332626
  9. How an acute rise in arterial pressure damages arterioles. Electron microscopic changes during angiotensin infusion.
    Cardiovasc Res. 1972 Sep;6(5):569-84 PMID: 4342509
  10. Role of the pressor action of angiotensin II in experimental hypertension.
    Circ Res. 1971 Dec;29(6):673-81 PMID: 4331483
  11. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.
    J Cell Biol. 1971 Jul;50(1):172-86 PMID: 4327464
  12. [Influence of differently induced forms of hypertension on MPS metabolism and structure of the aorta and large organic arteries].
    Exp Pathol (Jena). 1971;5(1):88-97 PMID: 4255520
  13. Arterial water, cations, and norepinephrine in early and late renovascular hypertension.
    Am J Physiol. 1975 May;228(5):1415-22 PMID: 165731
  14. Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro.
    Science. 1976 Feb 6;191(4226):475-7 PMID: 128820
  15. Increased incorporation of 14C-lysine into vascular proteins of the spontaneously hypertensive rat.
    Eur J Pharmacol. 1974 Nov;29(1):109-16 PMID: 4435034
  16. Modification of the effects of hypertension on lysosomes and connective tissue in the rat aorta.
    Circ Res. 1974 Feb;34(2):233-41 PMID: 4811077
  17. The myocardial interstitium: its structure and its role in ionic exchange.
    J Cell Biol. 1974 Mar;60(3):586-601 PMID: 4824287
  18. [Morphometric studies on changers in the aorta and coronary arteries due to experimental hypertension (author's transl)].
    Exp Pathol (Jena). 1973;8(3):168-81 PMID: 4777265
  19. Effect of tensile and shear stress on intimal permeability of the left coronary artery in dogs.
    Atherosclerosis. 1973 Sep-Oct;18(2):179-89 PMID: 4742849
  20. The cellular pathology of experimental hypertension. VI. Alterations in retinal vasculature.
    Am J Pathol. 1972 Jul;68(1):81-96 PMID: 5080700
  21. Lesions in elastic arteries associated with hypertension.
    Am J Pathol. 1948 Jan;24(1):195-209 PMID: 18921352
  22. THE CELLULAR PATHOLOGY OF EXPERIMENTAL HYPERTENSION. I. HYPERPLASTIC ARTERIOLARSCLEROSIS.
    Am J Pathol. 1965 Jul;47:19-49 PMID: 14308136
  23. The utilisation of tritiated thymidine for deoxyribonucleic acid synthesis by the lesions of experimental hypertension in rats.
    J Pathol Bacteriol. 1963 Jul;86:83-97 PMID: 14023683
  24. Sulphate utilisation and mucopolysaccharide synthesis by the mesenteric arteries of rats with experimental hypertension.
    J Pathol Bacteriol. 1962 Jul;84:113-22 PMID: 13882026
  25. The diffuse intimal thickening of the human aorta with aging.
    Am J Pathol. 1958 Nov-Dec;34(6):1023-31 PMID: 13583094
  26. Ionic composition of the aorta in renal and adrenal hypertension.
    Am J Physiol. 1958 Feb;192(2):325-30 PMID: 13508878
  27. Artery wall electrolytes in renal and DCA hypertension.
    J Clin Invest. 1954 Oct;33(10):1407-14 PMID: 13201647
  28. The human aorta. V. Collagen and elastin in the normal and hypertensive aorta.
    Acta Pathol Microbiol Scand. 1952;31(3):377-82 PMID: 12985344
  29. Tissue cations and water in arterial hypertension.
    Circulation. 1952 May;5(5):754-8 PMID: 14926060
  30. Fine structural evidence of specific mechanism for increased endothelial permeability in experimental hypertension.
    Am J Pathol. 1970 Dec;61(3):395-412 PMID: 4115158
  31. Effects of estrogen and progestogen treatment on the response of the aorta of male rats to hypertension. Morphological and chemical studies.
    Circ Res. 1972 Mar;30(3):341-9 PMID: 5060434
  32. Long-term effects of hypertension on the rat aortic wall and their relation to concurrent aging changes. Morphological and chemical studies.
    Circ Res. 1972 Mar;30(3):301-9 PMID: 5060432
  33. A lamellar unit of aortic medial structure and function in mammals.
    Circ Res. 1967 Jan;20(1):99-111 PMID: 4959753
  34. Development and maintenance of renal hypertension in normal and guanethidine sympathectomized rats.
    Circ Res. 1975 Jun;36(6 Suppl 1):171-8 PMID: 1093753
  35. Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta.
    Cardiovasc Res. 1976 Jul;10(4):437-51 PMID: 947333
  36. Hyperplasia of vascular smooth muscle in experimental hypertension in the rabbit.
    Circ Res. 1976 Jun;38(6 Suppl 2):58-62 PMID: 1269112
  37. Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium.
    Am J Pathol. 1976 Jul;84(1):111-38 PMID: 937512
  38. An autoradiographic and pathological study of cellular proliferation in rabbit arteries correlated with an increase in arterial pressure.
    Blood Vessels. 1976;13(1-2):100-28 PMID: 1247693
  39. Effect of the angiotensin II blocker 1-Sar-8-Ala-angiotensin II on renal artery clip hypertension in the rat.
    Circ Res. 1975 Nov;37(5):640-6 PMID: 1192561
  40. Plasma renin and sodium balance during development of moderate and severe renal hypertension in rats.
    Circ Res. 1975 Jun;36(6 Suppl 1):179-86 PMID: 1132077
  41. Effects of hypertension and its reversal on the thoracic aorta of male and female rats. Morphological and chemical studies.
    Circ Res. 1971 Jun;28(6):622-37 PMID: 5087325
  42. [Comparative histochemical studies on thickenings of the aortic wall in experimental hypertension in rats].
    Exp Pathol (Jena). 1971;5(1):59-70 PMID: 5098044
  43. Increased permeability of the arteries in hypertensive rats: an electron microscopic study.
    Exp Mol Pathol. 1971 Oct;15(2):198-208 PMID: 5111802
  44. Response of the rat aortic wall to hypertension: importance of comparing absolute amounts of wall components.
    Atherosclerosis. 1970 Mar-Apr;11(2):251-5 PMID: 5527515
  45. Arteriosclerosis of the mesenteric arteries of rats with renal hypertension. Electron microscopic observations.
    Am J Pathol. 1970 Dec;61(3):293-322 PMID: 5526230
  46. [Electron microscopic studies on early changes of coronary arteries in experimental hypertension].
    Beitr Pathol. 1970;141(4):374-91 PMID: 5490895
  47. Response of the rat aortic media to hypertension. Morphological and chemical studies.
    Circ Res. 1970 Apr;26(4):507-22 PMID: 5435712
  48. The cellular pathology of experimental hypertension. V. Increased permeability of cerebral arterial vessels.
    Am J Pathol. 1970 Apr;59(1):133-60 PMID: 5441715
  49. New cell formation in rats with accelerated hypertension due to partial aortic constriction.
    J Pathol. 1970 Apr;100(4):307-16 PMID: 5453372
  50. Morphology of early large vessel lesions in experimental hypertension.
    Br J Exp Pathol. 1969 Dec;50(6):600-4 PMID: 5364389
  51. Water content of arteriolar wall in renovascular hypertension.
    Am J Physiol. 1969 Jan;216(1):22-4 PMID: 5765586
  52. The cellular pathology of experimental hypertension. IV. Evidence for increased vascular permeability.
    Am J Pathol. 1969 Feb;54(2):187-207 PMID: 5765564
  53. The pathogenesis of the intimal thickenings produced by hypertension in large arteries in the rat.
    Lab Invest. 1968 Jul;19(1):84-91 PMID: 5671356
  54. Arterial wall metabolism in experimental hypertension of coarctation of the aorta of short duration.
    J Clin Invest. 1968 May;47(5):1221-9 PMID: 5645864
  55. The early effect of hypertension on the aortic intima of the rat. An electron microscopic study.
    Am J Pathol. 1967 Nov;51(5):721-34 PMID: 6054846
  56. Morphologic aspects of the arterial wall in spontaneously hypertensive rats (SHR).
    Arch Int Physiol Biochim. 1974;82(2):399-402 PMID: 4135893
Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1977-09-00
Pages
619-34
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032372
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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