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PMID: 8923478 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines.

Neurochemical research ·Vol. 21 ·No. 10 ·1996-10-00 ·Pages 1181-6

Summers KL, Lippiello P, Giacobini E

Abstract

Transcortical dialysis was employed to investigate the effects of subcutaneous (s.c.) injections of RJR-2403 (1.2-7.2 mumol/kg) on extracellular levels of acetylcholine (ACh), norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in rat. Systemic administration of RJR-2403 produced a 90% increase of cortical extracellular ACh levels that persisted for up to 90 minutes after injection. Norepinephrine and DA release were increased 124% and 131% above basal values, respectively. Serotonin (5-HT) levels in the dialysate were also significantly elevated by RJR-2403 (3.6 mumol/kg, s.c.) 70% above baseline at 90 minutes post-injection. Comparison of these responses to those of (-)nicotine from a previous study reveals little difference between the two compounds in their ability to influence cortical neurotransmitter release following systemic administration.

MeSH Terms
Acetylcholine/metabolism Animals Biogenic Amines/metabolism Cerebral Cortex/drug effects,metabolism Dopamine/metabolism Dose-Response Relationship, Drug Male Microdialysis Nicotine/analogs & derivatives,pharmacology Nicotinic Agonists/pharmacology Norepinephrine/metabolism Rats Rats, Sprague-Dawley Serotonin/metabolism
Chemicals
Biogenic Amines Nicotinic Agonists Serotonin metanicotine Nicotine Acetylcholine Dopamine Norepinephrine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Summers K L
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-1222, USA.
Lippiello P
Giacobini E
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF02532393
Published
1996-10-00
Pages
1181-6
Language
English
Region
United States
NLM ID
7613461
Subset
IM
Grants
NIA NIH HHS · P30 AG08014 · United States
External Links
PubMed source DOI: 10.1007/BF02532393 View journal details
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