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PMID: 8932319 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.

Journal of bacteriology ·Vol. 178 ·No. 22 ·1996-11-00 ·Pages 6618-22

Givskov M, de Nys R, Manefield M, Gram L, Maximilien R, Eberl L, Molin S, Steinberg PD, Kjelleberg S

Abstract

Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.

MeSH Terms

4-Butyrolactone/analogs & derivatives,metabolism Acylation Cell Communication Eukaryotic Cells/microbiology,physiology Lactones/metabolism Prokaryotic Cells/physiology Rhodophyta/microbiology,physiology Serratia/chemistry,physiology

Chemicals

Lactones homoserine lactone 4-Butyrolactone

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Givskov M

Department of Microbiology, The Technical University of Denmark, Lyngby.

de Nys R

Manefield M

Gram L

Maximilien R

Eberl L

Molin S

Steinberg P D

Kjelleberg S

References (13)

13 references, click to expand

Differentiation of Serratia marcescens 274 into swimmer and swarmer cells.
J Bacteriol. 1990 Aug;172(8):4322-8 PMID: 2198253
Analogs of the autoinducer of bioluminescence in Vibrio fischeri.
Arch Microbiol. 1986 Oct;146(1):35-40 PMID: 3813773
Impact of CLOD Pathogen on Pacific Coral Reefs.
Science. 1995 Mar 3;267(5202):1356-60 PMID: 17812612
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators.
J Bacteriol. 1994 Jan;176(2):269-75 PMID: 8288518
Cell differentiation of Proteus mirabilis is initiated by glutamine, a specific chemoattractant for swarming cells.
Mol Microbiol. 1993 Apr;8(1):53-60 PMID: 8497197
The genus Serratia.
Annu Rev Microbiol. 1978;32:221-48 PMID: 360966
Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens.
Mol Microbiol. 1996 Apr;20(1):127-36 PMID: 8861211
Differentiation of Serratia liquefaciens into swarm cells is controlled by the expression of the flhD master operon.
J Bacteriol. 1996 Jan;178(2):554-9 PMID: 8550481
Optical sectioning of microbial biofilms.
J Bacteriol. 1991 Oct;173(20):6558-67 PMID: 1917879
The bacterial 'enigma': cracking the code of cell-cell communication.
Mol Microbiol. 1995 May;16(4):615-24 PMID: 7476157
Bacterial swarming: an example of prokaryotic differentiation and multicellular behaviour.
Sci Prog. 1991;75(298 Pt 3-4):403-22 PMID: 1842857
Adsorption kinetics of laterally and polarly flagellated Vibrio.
J Bacteriol. 1982 Sep;151(3):1568-80 PMID: 7107559
Dimorphic transition in Escherichia coli and Salmonella typhimurium: surface-induced differentiation into hyperflagellate swarmer cells.
Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8631-5 PMID: 8078935

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.178.22.6618-6622.1996

Published

1996-11-00

Pages

6618-22

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC178549

Subset

External Links

PubMed source DOI: 10.1128/jb.178.22.6618-6622.1996 PMC Full Text View journal details

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Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.

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