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PMID: 8942955 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Toward a molecular definition of long-term memory storage.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 24 ·1996-11-26 ·Pages 13445-52

Bailey CH, Bartsch D, Kandel ER

Abstract

The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory processes, ranging in complexity from those produced by simple forms of implicit learning in invertebrates to those produced by more complex forms of explicit learning in mammals, suggest that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP-inducible cascade of genes and the recruitment of cAMP response element binding protein-related transcription factors. This conservation of steps in the mechanisms for learning-related synaptic plasticity suggests the possibility of a molecular biology of cognition.

MeSH Terms
Animals Aplysia Cognition/physiology Cyclic AMP/physiology Cyclic AMP Response Element-Binding Protein/biosynthesis,physiology Drosophila Gene Expression Genes, Immediate-Early Hippocampus/physiology Learning/physiology Long-Term Potentiation Mammals Memory/physiology Models, Neurological Neuronal Plasticity Reflex Synapses/physiology
Chemicals
Cyclic AMP Response Element-Binding Protein Cyclic AMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bailey C H
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia, University, New York State Psychiatric Institute, NY 10032, USA.
Bartsch D
Kandel E R
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.24.13445
Published
1996-11-26
Pages
13445-52
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33629
Subset
IM
Grants
NIMH NIH HHS · R01 MH037134 · United States
NIGMS NIH HHS · GM32099 · United States
NIMH NIH HHS · MH37134 · United States
External Links
PubMed source DOI: 10.1073/pnas.93.24.13445 PMC Full Text View journal details
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