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PMID: 9006985 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A pacemaker current in dye-coupled hilar interneurons contributes to the generation of giant GABAergic potentials in developing hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 4 ·1997-02-15 ·Pages 1435-46

Strata F, Atzori M, Molnar M, Ugolini G, Tempia F, Cherubini E

Abstract

The establishment of synaptic connections and their refinement during development require neural activity. Increasing evidence suggests that spontaneous bursts of neural activity within an immature network are mediated by gamma-aminobutyric acid via a paradoxical excitatory action. Our data show that in the developing hippocampus such synchronous burst activity is generated in the hilar region by transiently coupled cells. These cells have been identified as neuronal elements because they fire action potentials and they are not positive for the glial fibrillary acidic protein staining. Oscillations in hilar cells are "paced" by a hyperpolarization-activated current, with properties of Ih. Coactivated interneurons synchronously release GABA, which via its excitatory action may serve a neurotrophic function during the refinement of hippocampal circuitry.

MeSH Terms
Aging/physiology Animals Animals, Newborn/growth & development,physiology Cations/metabolism Electric Conductivity Electrophysiology Hippocampus/cytology,growth & development,physiology Interneurons/physiology Neurons/physiology Periodicity Rats Rats, Wistar Receptors, GABA-A/physiology gamma-Aminobutyric Acid/physiology
Chemicals
Cations Receptors, GABA-A gamma-Aminobutyric Acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Strata F
Biophysics Laboratory, International School for Advanced Studies (SISSA), 34014 Trieste, Italy.
Atzori M
Molnar M
Ugolini G
Tempia F
Cherubini E
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-02-15
Pages
1435-46
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793743
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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