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PMID: 9016591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

DIR: a novel DNA rearrangement associated with inverted repeats.

Nucleic acids research ·Vol. 25 ·No. 3 ·1997-02-01 ·Pages 523-9

Pinder DJ, Blake CE, Leach DR

Abstract

A novel DNA rearrangement has been characterised that is both a direct and inverted repeat. This rearrangement involves the 2-fold duplication of a plasmid sequence adjacent to the site of insertion of a long palindrome. The sequence of this rearrangement suggests that it has arisen by strand slippage from the leading to the lagging strand of the replication fork as a consequence of the presence of the long palindrome.

MeSH Terms
Deoxyribonuclease BamHI/metabolism Deoxyribonuclease EcoRI/metabolism Electrophoresis, Agar Gel Electrophoresis, Polyacrylamide Gel Gene Rearrangement Mutagenesis, Insertional Plasmids Repetitive Sequences, Nucleic Acid
Chemicals
Deoxyribonuclease BamHI Deoxyribonuclease EcoRI
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pinder D J
Institute of Cell and Molecular Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JR, UK.
Blake C E
Leach D R
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/25.3.523
Published
1997-02-01
Pages
523-9
Language
English
Region
England
NLM ID
0411011
PMCID
PMC146454
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/25.3.523 PMC Full Text View journal details
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