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PMID: 9064355 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

The Journal of experimental medicine ·Vol. 184 ·No. 3 ·1996-09-01 ·Pages 955-61

Guo Y, Wu Y, Shinde S, Sy MS, Aruffo A, Liu Y

Abstract

The interaction between CD40 ligand and CD40 is critical for activation of T and B cells in vivo. We have recently demonstrated that this interaction rapidly induces a novel costimulatory activity distinct from B7 and independent of CD28. To study the molecular basis of the costimulatory activity, we have produced a novel monoclonal antibody, TM-1, that binds an 85-kilodalton costimulatory molecule rapidly induced by CD40L. Expression cloning reveals that TM-1 binds CD44H. CD44H expressed on Chinese hamster ovary cells has potent costimulatory activity for clonal expansion of T cells isolated from both wild-type mice and these with a targeted mutation of CD28. Thus, CD44H costimulates T cell proliferation by a CD28-independent mechanism. These results revealed that CD44H is a costimulatory molecule rapidly induced by CD40L.

MeSH Terms
Animals Antibodies, Monoclonal CD40 Antigens/metabolism CD40 Ligand CHO Cells Cloning, Molecular Cricetinae Hyaluronan Receptors/metabolism Membrane Glycoproteins/metabolism Mice Mice, Inbred C57BL Mice, Inbred CBA RNA, Messenger/metabolism Spectrometry, Fluorescence
Chemicals
Antibodies, Monoclonal CD40 Antigens Hyaluronan Receptors Membrane Glycoproteins RNA, Messenger CD40 Ligand
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Guo Y
Michael Heidelberger Division of Immunology, Department of Pathology, New York University Medical Center, New York 10016, USA.
Wu Y
Shinde S
Sy M S
Aruffo A
Liu Y
References (39)
39 references, click to expand
  1. CD40 ligand-transduced co-stimulation of T cells in the development of helper function.
    Nature. 1995 Dec 7;378(6557):620-3 PMID: 8524396
  2. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand.
    Nature. 1995 Dec 7;378(6557):617-20 PMID: 8524395
  3. A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid.
    J Exp Med. 1996 May 1;183(5):1987-94 PMID: 8642309
  4. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept.
    Annu Rev Immunol. 1983;1:143-73 PMID: 6443557
  5. Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.
    J Immunol. 1987 May 15;138(10):3120-9 PMID: 3106474
  6. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.
    Proc Natl Acad Sci U S A. 1987 May;84(10):3365-9 PMID: 2437578
  7. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.
    J Cell Biol. 1987 Oct;105(4):1873-84 PMID: 2822727
  8. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy.
    Annu Rev Immunol. 1989;7:445-80 PMID: 2653373
  9. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.
    J Exp Med. 1990 May 1;171(5):1753-71 PMID: 2185332
  10. CD44 is the principal cell surface receptor for hyaluronate.
    Cell. 1990 Jun 29;61(7):1303-13 PMID: 1694723
  11. Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44.
    J Immunol. 1991 Oct 15;147(8):2493-9 PMID: 1833455
  12. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.
    J Cell Biol. 1992 Feb;116(3):817-25 PMID: 1730778
  13. Costimulation of T-cell growth.
    Curr Opin Immunol. 1992 Jun;4(3):265-70 PMID: 1418704
  14. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
    Cell. 1993 Jan 29;72(2):291-300 PMID: 7678782
  15. CD40 ligand mutations in x-linked immunodeficiency with hyper-IgM.
    Nature. 1993 Feb 11;361(6412):541-3 PMID: 8094231
  16. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.
    J Exp Med. 1993 Apr 1;177(4):925-35 PMID: 7681471
  17. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.
    Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2170-3 PMID: 7681587
  18. Differential T cell costimulatory requirements in CD28-deficient mice.
    Science. 1993 Jul 30;261(5121):609-12 PMID: 7688139
  19. The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.
    Cell. 1993 Jul 30;74(2):257-68 PMID: 8343954
  20. CD44 and its interaction with extracellular matrix.
    Adv Immunol. 1993;54:271-335 PMID: 8379464
  21. A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.
    J Exp Med. 1993 Nov 1;178(5):1789-93 PMID: 8228824
  22. CD44 expression on activated B cells. Differential capacity for CD44-dependent binding to hyaluronic acid.
    J Immunol. 1993 Dec 15;151(12):6712-22 PMID: 7505013
  23. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.
    EMBO J. 1994 Jan 15;13(2):286-96 PMID: 7508860
  24. How B and T cells talk to each other.
    Nature. 1994 Feb 3;367(6462):425-8 PMID: 8107800
  25. CD40 preferentially costimulates activation of CD4+ T lymphocytes.
    J Immunol. 1994 Feb 15;152(4):1523-31 PMID: 7509825
  26. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.
    J Exp Med. 1994 Jul 1;180(1):141-55 PMID: 7516404
  27. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.
    J Exp Med. 1994 Jul 1;180(1):157-63 PMID: 7516405
  28. Induction of B cell costimulatory function by recombinant murine CD40 ligand.
    Eur J Immunol. 1994 Jan;24(1):116-23 PMID: 7517359
  29. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.
    J Cell Biol. 1994 Aug;126(4):1099-109 PMID: 7519619
  30. Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain.
    J Exp Med. 1995 Jan 1;181(1):55-62 PMID: 7528778
  31. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses.
    Eur J Immunol. 1995 Feb;25(2):596-603 PMID: 7533092
  32. Mice deficient for the CD40 ligand.
    Immunity. 1994 Aug;1(5):423-31 PMID: 7882172
  33. Absence of B7-dependent responses in CD28-deficient mice.
    Immunity. 1994 Sep;1(6):501-8 PMID: 7534617
  34. Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain.
    J Exp Med. 1995 Apr 1;181(4):1345-55 PMID: 7535334
  35. A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation.
    J Biol Chem. 1995 Mar 31;270(13):7437-44 PMID: 7535771
  36. Adhesive interactions between alternatively spliced CD44 isoforms.
    J Biol Chem. 1995 May 12;270(19):11567-73 PMID: 7538117
  37. In the absence of a CD40 signal, B cells are tolerogenic.
    Immunity. 1995 Jun;2(6):645-53 PMID: 7540943
  38. Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.
    Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8200-4 PMID: 7545296
  39. Rapid induction of a novel costimulatory activity on B cells by CD40 ligand.
    Curr Biol. 1995 Nov 1;5(11):1303-11 PMID: 8574588
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.184.3.955
Published
1996-09-01
Pages
955-61
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192764
Subset
IM
Grants
NIAID NIH HHS · AI32981 · United States
External Links
PubMed source DOI: 10.1084/jem.184.3.955 PMC Full Text View journal details
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