Home LiteratureArticle Details
PMID: 9169538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regional cerebral blood flow changes as a function of delta and spindle activity during slow wave sleep in humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 12 ·1997-06-15 ·Pages 4800-8

Hofle N, Paus T, Reutens D, Fiset P, Gotman J, Evans AC, Jones BE

Abstract

In the present study, we investigated changes in regional cerebral blood flow (rCBF) in humans during the progression from relaxed wakefulness through slow wave sleep (SWS). These changes were examined as a function of spindle (12-15 Hz) and delta (1.5-4.0 Hz) electroencephalographic (EEG) activity of SWS. rCBF was studied with positron emission tomography (PET) using the H215O bolus method. A maximum of six 60 sec scans were performed per subject during periods of wakefulness and stages 1-4 of SWS, as determined by on-line EEG monitoring. Spectral analysis was performed off-line on the EEG epochs corresponding to the scans for computation of activity in specific frequency bands. The relationship between EEG frequency band activity and normalized rCBF was determined by means of a voxel-by-voxel analysis of covariance. delta activity covaried negatively with rCBF most markedly in the thalamus and also in the brainstem reticular formation, cerebellum, anterior cingulate, and orbitofrontal cortex. After the effect of delta was removed, a significant negative covariation between spindle activity and the residual rCBF was evident in the medial thalamus. These negative covariations may reflect the disfacilitation and active inhibition of thalamocortical relay neurons in association with delta and spindles, as well as the neural substrates underlying the progressive attenuation of sensory awareness, motor responsiveness, and arousal that occur during SWS. delta activity covaried positively with rCBF in the visual and auditory cortex, possibly reflecting processes of dream-like mentation purported to occur during SWS.

MeSH Terms
Adult Brain/blood supply,diagnostic imaging,physiology Delta Rhythm Electroencephalography Electromyography Electrooculography Female Humans Male Regional Blood Flow Sleep Stages/physiology Tomography, Emission-Computed Wakefulness/physiology
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Hofle N
McConnell Brain Imaging Centre, Montreal Neurological Institute, Montréal, Québec, Canada H3A 2B4.
Paus T
Reutens D
Fiset P
Gotman J
Evans A C
Jones B E
References (54)
54 references, click to expand
  1. The effects of sleep and lack of sleep on the cerebral circulation and metabolism of normal young men.
    J Clin Invest. 1955 Jul;34(7, Part 1):1092-1100 PMID: 14392224
  2. GABA neurons are the major cell type of the nucleus reticularis thalami.
    Brain Res. 1980 Nov 3;200(2):341-54 PMID: 7417821
  3. Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography.
    Life Sci. 1989;45(15):1349-56 PMID: 2796606
  4. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity.
    Prog Neurobiol. 1992 Oct;39(4):337-88 PMID: 1354387
  5. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
    Proc Natl Acad Sci U S A. 1989 Jul;86(13):5159-62 PMID: 2567995
  6. Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei.
    N Engl J Med. 1986 Oct 16;315(16):997-1003 PMID: 3762620
  7. Cerebral blood flow in normal and abnormal sleep and dreaming.
    Brain Cogn. 1987 Jul;6(3):266-94 PMID: 3606861
  8. Effects of hemi-thalamic damage on K-complexes evoked by monaural stimuli during midafternoon sleep.
    Electroencephalogr Clin Neurophysiol. 1995 Feb;94(2):148-50 PMID: 7532574
  9. Tonic and phasic events during sleep: psychological correlates and implications.
    Percept Mot Skills. 1969 Oct;29(2):343-68 PMID: 4310916
  10. Cerebral blood flow and metabolism during sleep.
    Cerebrovasc Brain Metab Rev. 1991 Winter;3(4):281-96 PMID: 1772738
  11. Modulation of cerebral blood flow in the human auditory cortex during speech: role of motor-to-sensory discharges.
    Eur J Neurosci. 1996 Nov;8(11):2236-46 PMID: 8950088
  12. Topographical organization of the projections from the reticular thalamic nucleus to the intralaminar and medial thalamic nuclei in the cat.
    J Comp Neurol. 1989 Jan 15;279(3):457-69 PMID: 2918081
  13. Thalamic projections of nucleus reticularis thalami of cat: a study using retrograde transport of horseradish peroxidase and fluorescent tracers.
    J Comp Neurol. 1984 Nov 10;229(4):531-47 PMID: 6209310
  14. Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.
    Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6649-52 PMID: 1378632
  15. Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
    J Nucl Med. 1983 Sep;24(9):790-8 PMID: 6604140
  16. Cerebral O2 metabolism and cerebral blood flow in humans during deep and rapid-eye-movement sleep.
    J Appl Physiol (1985). 1991 Jun;70(6):2597-601 PMID: 1885454
  17. Enhanced detection of focal brain responses using intersubject averaging and change-distribution analysis of subtracted PET images.
    J Cereb Blood Flow Metab. 1988 Oct;8(5):642-53 PMID: 3262113
  18. Cerebral oxygen metabolism and cerebral blood flow in man during light sleep (stage 2).
    Brain Res. 1991 Aug 23;557(1-2):217-20 PMID: 1747754
  19. Cerebral glucose utilization during sleep-wake cycle in man determined by positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose method.
    Brain Res. 1990 Apr 9;513(1):136-43 PMID: 2350676
  20. Extraretinal modulation of cerebral blood flow in the human visual cortex: implications for saccadic suppression.
    J Neurophysiol. 1995 Nov;74(5):2179-83 PMID: 8592206
  21. Cognitive and language functions of the human cerebellum.
    Trends Neurosci. 1993 Nov;16(11):444-7 PMID: 7507614
  22. Reports of mental activity from sleep stages 2 and 4.
    Percept Mot Skills. 1974 Apr;38(2):647-8 PMID: 4824104
  23. Synchronized sleep oscillations and their paroxysmal developments.
    Trends Neurosci. 1994 May;17(5):199-208 PMID: 7520202
  24. The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming.
    J Exp Psychol. 1957 May;53(5):339-46 PMID: 13428941
  25. Lateralization of phonetic and pitch discrimination in speech processing.
    Science. 1992 May 8;256(5058):846-9 PMID: 1589767
  26. A three-dimensional statistical analysis for CBF activation studies in human brain.
    J Cereb Blood Flow Metab. 1992 Nov;12(6):900-18 PMID: 1400644
  27. Mechanisms of long-lasting hyperpolarizations underlying slow sleep oscillations in cat corticothalamic networks.
    J Physiol. 1996 Jul 1;494 ( Pt 1):251-64 PMID: 8814619
  28. Relationship between cerebral blood flow velocities and cerebral electrical activity in sleep.
    Sleep. 1994 Feb;17(1):11-9 PMID: 7910702
  29. Cellular mechanisms of a synchronized oscillation in the thalamus.
    Science. 1993 Jul 16;261(5119):361-4 PMID: 8392750
  30. Regulation of the cerebral microcirculation during neural activity: is nitric oxide the missing link?
    Trends Neurosci. 1993 Jun;16(6):206-14 PMID: 7688160
  31. The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
    J Cereb Blood Flow Metab. 1988 Jun;8(3):314-23 PMID: 3366794
  32. Hearing in the Mind's Ear: A PET Investigation of Musical Imagery and Perception.
    J Cogn Neurosci. 1996 Winter;8(1):29-46 PMID: 23972234
  33. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space.
    J Comput Assist Tomogr. 1994 Mar-Apr;18(2):192-205 PMID: 8126267
  34. Pseudo-hypersomnia and pre-sleep behaviour with bilateral paramedian thalamic lesions.
    Brain. 1993 Dec;116 ( Pt 6):1549-63 PMID: 8293287
  35. Human regional cerebral blood flow during rapid-eye-movement sleep.
    J Cereb Blood Flow Metab. 1991 May;11(3):502-7 PMID: 2016359
  36. Topographical representations of mental images in primary visual cortex.
    Nature. 1995 Nov 30;378(6556):496-8 PMID: 7477406
  37. Dream reports from different stages of sleep.
    J Abnorm Soc Psychol. 1962 Jul;65:14-25 PMID: 13894288
  38. The neural correlates of the verbal component of working memory.
    Nature. 1993 Mar 25;362(6418):342-5 PMID: 8455719
  39. Slow wave sleep dreaming.
    Sleep. 1992 Dec;15(6):562-6 PMID: 1475572
  40. The thalamus as a neuronal oscillator.
    Brain Res. 1984 Nov;320(1):1-63 PMID: 6440659
  41. Time-related changes in neural systems underlying attention and arousal during the performance of an auditory vigilance task.
    J Cogn Neurosci. 1997 May;9(3):392-408 PMID: 23965014
  42. PET studies of phonetic processing of speech: review, replication, and reanalysis.
    Cereb Cortex. 1996 Jan-Feb;6(1):21-30 PMID: 8670635
  43. The cortical localization of the lexicons. Positron emission tomography evidence.
    Brain. 1992 Dec;115 ( Pt 6):1769-82 PMID: 1486460
  44. Normal human sleep: regional cerebral hemodynamics.
    Ann Neurol. 1980 May;7(5):471-8 PMID: 7396425
  45. Primary visual experience and secondary cognitive elaboration in stage REM: a modest confirmation and an extension.
    Percept Mot Skills. 1973 Aug;37(1):107-18 PMID: 4353828
  46. The functional states of the thalamus and the associated neuronal interplay.
    Physiol Rev. 1988 Jul;68(3):649-742 PMID: 2839857
  47. Functional neuroanatomy of human rapid-eye-movement sleep and dreaming.
    Nature. 1996 Sep 12;383(6596):163-6 PMID: 8774879
  48. Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis.
    J Nucl Med. 1983 Sep;24(9):782-9 PMID: 6604139
  49. Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships.
    J Neurosci. 1995 Jan;15(1 Pt 2):604-22 PMID: 7823167
  50. MRI-PET registration with automated algorithm.
    J Comput Assist Tomogr. 1993 Jul-Aug;17(4):536-46 PMID: 8331222
  51. Cerebral glucose utilization during stage 2 sleep in man.
    Brain Res. 1992 Jan 31;571(1):149-53 PMID: 1611488
  52. Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard.
    Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10 PMID: 11422885
  53. Sleep-related variations of membrane potential in the lateral geniculate body relay neurons of the cat.
    Brain Res. 1983 Jan 24;259(2):308-12 PMID: 6297675
  54. The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat.
    J Comp Neurol. 1985 Dec 1;242(1):56-92 PMID: 2416786
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-06-15
Pages
4800-8
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6573353
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2