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PMID: 9194178 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

MultiCoil: a program for predicting two- and three-stranded coiled coils.

Protein science : a publication of the Protein Society ·Vol. 6 ·No. 6 ·1997-06-00 ·Pages 1179-89

Wolf E, Kim PS, Berger B

Abstract

A new multidimensional scoring approach for identifying and distinguishing trimeric and dimeric coiled coils is implemented in the MultiCoil program. The program extends the two-stranded coiled-coil prediction program PairCoil to the identification of three-stranded coiled coils. The computations are based upon data gathered from a three-stranded coiled-coil database comprising 6,319 amino acid residues, as well as from the previously constructed two-stranded coiled-coil database. In addition to identifying coiled coils not predicted by the two-stranded database programs, MultiCoil accurately classifies the oligomerization states of known dimeric and trimeric coiled coils. Analysis of the MultiCoil scores provides insight into structural features of coiled coils, and yields estimates that 0.9% of all protein residues form three-stranded coiled coils and that 1.5% form two-stranded coiled coils. The MultiCoil program is available at http:/(/)theory.lcs.mit.edu/multicoil.

MeSH Terms
Algorithms Databases, Factual Forecasting Molecular Sequence Data Probability Protein Folding Protein Structure, Secondary Reproducibility of Results Software
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wolf E
Howard Hughes Medical Institute, Whitehead Institute, MIT, Cambridge, Massachusetts 02142, USA.
Kim P S
Berger B
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1002/pro.5560060606
Published
1997-06-00
Pages
1179-89
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2143730
Subset
IM
Grants
NIGMS NIH HHS · GM44162 · United States
Databases
GENBANK
L32317, X14519, X91257
SWISSPROT
P03051
External Links
PubMed source DOI: 10.1002/pro.5560060606 PMC Full Text View journal details
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