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PMID: 9215920 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A test of neutrality based on interlocus associations.

Genetics ·Vol. 146 ·No. 3 ·1997-07-00 ·Pages 1197-206

Kelly JK

Abstract

The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. This measure, denoted ZnS, is based on the squared correlation of allelic identity at pairs of polymorphic sites. Upper bounds for ZnS are determined by simulations. Various deviations from the neutral model, including several different forms of natural selection, will inflate the value of ZnS relative to its neutral theory expectations. Larger than expected values of ZnS are observed in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.

MeSH Terms
Alcohol Dehydrogenase/genetics Alleles Animals Biological Evolution Chromosome Mapping Computer Simulation Drosophila melanogaster/enzymology,genetics Linkage Disequilibrium Mathematical Computing Models, Genetic Mutation
Chemicals
Alcohol Dehydrogenase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kelly J K
Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA. [email protected]
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/146.3.1197
Email
[email protected]
Published
1997-07-00
Pages
1197-206
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1208047
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/146.3.1197 PMC Full Text View journal details
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