On the classification and evolution of protein modules.

Journal of protein chemistry ·Vol. 16 ·No. 5 ·1997-07-00 ·Pages 545-51

Hegyi H, Bork P

Abstract

Our efforts to classify the functional units of many proteins, the modules, are reviewed. The data from the sequencing projects for various model organisms are extremely helpful in deducing the evolution of proteins and modules. For example, a dramatic increase of modular proteins can be observed from yeast to C. elegans in accordance with new protein functions that had to be introduced in multicellular organisms. Our sequence characterization of modules relies on sensitive similarity search algorithms and the collection of multiple sequence alignments for each module. To trace the evolution of modules and to further automate the classification, we have developed a sequence and a module alerting system that checks newly arriving sequence data for the presence of already classified modules. Using these systems, we were able to identify an unexpected similarity between extracellular C1Q modules with bacterial proteins.

MeSH Terms

Amino Acid Sequence Animals Genome Humans Molecular Sequence Data Protein Conformation Protein Structure, Tertiary Proteins/chemistry,classification,physiology

Chemicals

Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hegyi H

EMBL, Heidelberg, Germany.

Bork P

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27 references, click to expand

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Article Info

Journal

Journal of protein chemistry

Abbr.

J Protein Chem

ISSN

0277-8033

DOI

10.1023/a:1026382032119

Published

1997-07-00

Pages

545-51

Language

English

Region

United States

NLM ID

8217321

Subset

Databases

GENBANK

D45371, S79214, U27109, U37222, X65121, X98568, Z70177

SWISSPROT

P02745, P02746, P02747, P08125, P14106, P14282, P23206, P23435, P25067, P25318, P27658, P31721, P45938, P98085, P98086, P98087, Q00780, Q021505, Q05306, Q06575, Q06576, Q06577

External Links

PubMed source DOI: 10.1023/a:1026382032119

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