Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins.

Antimicrobial agents and chemotherapy ·Vol. 41 ·No. 11 ·1997-11-00 ·Pages 2544-6

Deguchi T, Yasuda M, KawamuraT, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Kawada Y

Abstract

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.

MeSH Terms

Anti-Infective Agents/pharmacology DNA Gyrase DNA Topoisomerase IV DNA Topoisomerases, Type II/drug effects Enterobacter cloacae/drug effects Fluoroquinolones Klebsiella pneumoniae/drug effects Microbial Sensitivity Tests Quinolones/pharmacology

Chemicals

Anti-Infective Agents Fluoroquinolones Quinolones sitafloxacin DNA Topoisomerase IV DNA Gyrase DNA Topoisomerases, Type II

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Deguchi T

Department of Urology, Gifu University School of Medicine, Japan.

Yasuda M

KawamuraT

Nakano M

Ozeki S

Kanematsu E

Nishino Y

Kawada Y

References (15)

15 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.41.11.2544

Published

1997-11-00

Pages

2544-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC164159

Subset

External Links

PubMed source DOI: 10.1128/AAC.41.11.2544 PMC Full Text View journal details

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Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins.

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