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PMID: 9378491 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interleukin-10 modulates susceptibility in experimental cerebral malaria.

Immunology ·Vol. 91 ·No. 4 ·1997-08-00 ·Pages 536-40

Kossodo S, Monso C, Juillard P, Velu T, Goldman M, Grau GE

Abstract

In this study, we examined the effects of interleukin-10 (IL-10) on the outcome of experimental cerebral malaria (CM), a lethal neurological syndrome that occurs in susceptible strains of mice after infection with Plasmodium berghei ANKA (PbA). Constitutive IL-10 mRNA levels were significantly higher in the spleen and brain of resistant animals. In vivo neutralization of endogenous IL-10 in CM-resistant mice induced the neurological syndrome in 35.7% of these mice, as opposed to 7.7% in controls. IL-10 inhibited PbA antigen-specific interferon-gamma (IFN-gamma) production in vitro but not tumour necrosis factor (TNF) serum levels in vivo. Susceptible mice, on the other hand, were significantly protected against CM when injected with recombinant IL-10. Overall, our findings suggest that IL-10 plays a protective role against experimental cerebral malaria.

MeSH Terms
Animals Disease Susceptibility Gene Expression Interferon-gamma/biosynthesis Interleukin-10/genetics,immunology,therapeutic use Malaria, Cerebral/immunology,therapy Mice Mice, Inbred BALB C Mice, Inbred CBA Plasmodium berghei RNA, Messenger/genetics Recombinant Proteins/therapeutic use Tumor Necrosis Factor-alpha/metabolism
Chemicals
RNA, Messenger Recombinant Proteins Tumor Necrosis Factor-alpha Interleukin-10 Interferon-gamma
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kossodo S
Department of Anaesthesiology, University of Geneva, Switzerland.
Monso C
Juillard P
Velu T
Goldman M
Grau G E
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1046/j.1365-2567.1997.00290.x
Published
1997-08-00
Pages
536-40
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1363872
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2567.1997.00290.x PMC Full Text View journal details
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