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PMID: 9383072 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Patterns of DNA variability at X-linked loci in Mus domesticus.

Genetics ·Vol. 147 ·No. 3 ·1997-11-00 ·Pages 1303-16

Nachman MW

Abstract

Introns of four X-linked genes (Hprt, Plp, Glra2, and Amg) were sequenced to provide an estimate of nucleotide diversity at nuclear genes within the house mouse and to test the neutral prediction that the ratio of intraspecific polymorphism to interspecific divergence is the same for different loci. Hprt and Plp lie in a region of the X chromosome that experiences relatively low recombination rates, while Glra2 and Amg lie near the telomere of the X chromosome, a region that experiences higher recombination rates. A total of 6022 bases were sequenced in each of 10 Mus domesticus and one M. caroli. Average nucleotide diversity (pi) for introns within M. domesticus was quite low (pi = 0.078%). However, there was substantial variation in the level of heterozygosity among loci. The two telomeric loci, Glra2 and Amg, had higher ratios of polymorphism to divergence than the two loci experiencing lower recombination rates. These results are consistent with the hypothesis that heterozygosity is reduced in regions with lower rates of recombination, although sampling of additional genes is needed to establish whether there is a general correlation between heterozygosity and recombination rate as in Drosophila melanogaster.

MeSH Terms
Amelogenin Animals Base Sequence Chromosome Mapping DNA Dental Enamel Proteins/genetics Genetic Variation Hypoxanthine Phosphoribosyltransferase/genetics Introns Male Mice Molecular Sequence Data Myelin Proteolipid Protein/genetics Receptors, Glycine/genetics X Chromosome
Chemicals
Amelogenin Amelx protein, mouse Dental Enamel Proteins Myelin Proteolipid Protein Receptors, Glycine DNA Hypoxanthine Phosphoribosyltransferase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nachman M W
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA. [email protected]
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/147.3.1303
Email
[email protected]
Published
1997-11-00
Pages
1303-16
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1208253
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/147.3.1303 PMC Full Text View journal details
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