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PMID: 9405656 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 26 ·1997-12-23 ·Pages 14584-9

Inoue H, Ishii H, Alder H, Snyder E, Druck T, Huebner K, Croce CM

Abstract

The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.

MeSH Terms
Acid Anhydride Hydrolases Chromosome Fragile Sites Chromosome Fragility Gene Deletion Humans Molecular Sequence Data Neoplasm Proteins Proteins/genetics Recombination, Genetic Tumor Cells, Cultured
Chemicals
Neoplasm Proteins Proteins fragile histidine triad protein Acid Anhydride Hydrolases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Inoue H
Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA.
Ishii H
Alder H
Snyder E
Druck T
Huebner K
Croce C M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.26.14584
Published
1997-12-23
Pages
14584-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC25062
Subset
IM
Grants
NCI NIH HHS · CA21124 · United States
NCI NIH HHS · CA39860 · United States
NCI NIH HHS · CA51083 · United States
Databases
GENBANK
AF019967, AF020503, AF020504, AF020609, AF020610, AF020611, AF020612, AF020613, AF020614, AF020615
External Links
PubMed source DOI: 10.1073/pnas.94.26.14584 PMC Full Text View journal details
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