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PMID: 9482938 Published · ppublish English Journal Article

Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 5 ·1998-03-03 ·Pages 2630-5

Zimmer A, Zimmer AM, Baffi J, Usdin T, Reynolds K, König M, Palkovits M, Mezey E

Abstract

The tachykinin neuropeptides, substance P and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling. However, the precise role and importance of these neuropeptides in pain responses has been debated. We now show that mice that cannot produce these peptides display no significant pain responses following formalin injection and have an increased pain threshold in the hotplate test. On the other hand, the mutant mice react normally in the tail flick assay and acetic acid-induced writhing tests. These results demonstrate that substance P and/or substance K have essential functions in specific responses to pain.

MeSH Terms
Acetic Acid Alleles Animals Biomarkers Calcitonin Gene-Related Peptide/biosynthesis Formaldehyde Ganglia, Spinal/metabolism Gene Deletion In Situ Hybridization Mice Mice, Inbred C57BL Mice, Knockout Neurokinin A/biosynthesis,deficiency,genetics Neurons/metabolism Pain/genetics,physiopathology Spinal Cord/metabolism Substance P/biosynthesis,deficiency,genetics
Chemicals
Biomarkers Formaldehyde Substance P Neurokinin A Calcitonin Gene-Related Peptide Acetic Acid
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Zimmer A
Section on Genetics, National Institute of Mental Health, Bethesda, MD 20892, USA. [email protected]
Zimmer A M
Baffi J
Usdin T
Reynolds K
König M
Palkovits M
Mezey E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.5.2630
Email
[email protected]
Published
1998-03-03
Pages
2630-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC19441
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.95.5.2630 PMC Full Text View journal details
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