Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats.

The Biochemical journal ·Vol. 155 ·No. 3 ·1976-06-01 ·Pages 709-12

Penn NW

Abstract

The mol percentage of 5-hydroxymethylcytosine is 2.2 times greater in the adult than in 2-day-old rat brain DNA. The concentration of 5-hydroxymethylcytosine falls in corresponding liver DNA preparations. This normal increase in brain 5-hydroxymethylcytosine is abolished in rats placed on an 8%-protein diet 5 days after birth.

MeSH Terms

Age Factors Animals Animals, Newborn Base Sequence Brain/growth & development,metabolism Cytosine/analysis DNA/metabolism Female Liver/analysis Male Nutrition Disorders/metabolism Protein Deficiency/metabolism Rats

Chemicals

Cytosine DNA

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Penn N W

References (20)

20 references, click to expand

The effects of growth and sex on the composition of the liver cells of the rat.
J Endocrinol. 1950 Jan;6(3):308-18 PMID: 15409389
THE DETERMINATION OF DEOXYRIBONUCLEIC ACID AND OF CELL NUMBER IN BRAIN.
J Neurochem. 1964 Jul;11:505-9 PMID: 14200773
The origin of purine and pyrimidine deoxyribose in T6r+ bacteriophage.
J Biol Chem. 1959 Feb;234(2):364-9 PMID: 13630912
The composition of the deoxyribonucleic acid of salmon sperm.
J Biol Chem. 1951 Sep;192(1):223-30 PMID: 14917668
The purine and pyrimidine composition of deoxypentose nucleic acids.
Biochem J. 1951 May;48(5):584-90 PMID: 14838906
Age related differences in the association of brain DNA and nuclear protein.
Biochim Biophys Acta. 1967;145(3):840-2 PMID: 6065701
Ethanol antagonism by 5-hydroxymethyl cellular compounds.
Life Sci. 1975 Oct 10;17(7):1055-61 PMID: 1195994
Loss of genes coding for ribosomal RNA in ageing brain cells.
Nature. 1972 Dec 15;240(5381):412-4 PMID: 4564320
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid.
Biochem J. 1972 Feb;126(4):781-90 PMID: 4538516
The turnover of isotopically labelled DNA in vivo in developing, adult and Scrapie-affected mouse brain.
J Neurochem. 1974 Jul;23(1):241-8 PMID: 4859554
Heterogenous rapidly labeled DNA with the properties of replicating form in isolated rat liver mitochondria.
Biochim Biophys Acta. 1973 Jun 23;312(2):179-91 PMID: 4723230
Changes in the structure of rat liver DNA in relation to age.
Arch Biochem Biophys. 1972 Dec;153(2):736-41 PMID: 4662107
Nucleic acids in chloroplasts and metabolic DNA.
Prog Nucleic Acid Res Mol Biol. 1966;5:133-55 PMID: 5337695
Age-related changes in a spontaneously reassociating fraction of mouse DNA.
Mech Ageing Dev. 1975 May-Aug;4(3-4):181-9 PMID: 1195786
Antagonism of barbiturate by DNA pyrimidines and allied compounds.
Arch Int Pharmacodyn Ther. 1975 Nov;218(1):156-66 PMID: 1212013
Single-stranded regions in DNA of old mice.
Nature. 1975 Jan 10;253(5487):130-1 PMID: 1110761
Age-associated changes in the DNA of mouse tissue.
Science. 1971 Mar 5;171(3974):917-20 PMID: 5541658
Effect of malnutrition on regional growth of the developing rat brain.
Exp Neurol. 1969 Dec;25(4):534-40 PMID: 5362568
Undernutrition and cerebellar development.
Nature. 1969 Feb 8;221(5180):554-5 PMID: 5789301
H3-thymidine incorporation and mitotic activity in liver of rats of various ages.
Gerontologia. 1966;12(2):79-88 PMID: 5915635

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1550709

Published

1976-06-01

Pages

709-12

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1172897

Subset

External Links

PubMed source DOI: 10.1042/bj1550709 PMC Full Text View journal details

Analysis Services

Modification of brain deoxyribonucleic acid base content with maturation in normal and malnourished rats.

Contact

WeChat Official Account