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PMID: 9584139 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo.

The Journal of experimental medicine ·Vol. 187 ·No. 10 ·1998-05-18 ·Pages 1611-21

Townsend SE, Goodnow CC

Abstract

Antigen-specific B cells are implicated as antigen-presenting cells in memory and tolerance responses because they capture antigens efficiently and localize to T cell zones after antigen capture. It has not been possible, however, to visualize the effect of specific B cells on specific CD4+ helper T cells under physiological conditions. We demonstrate here that rare T cells are activated in vivo by minute quantities of antigen captured by antigen-specific B cells. Antigen-activated B cells are helped under these conditions, whereas antigen-tolerant B cells are killed. The T cells proliferate and then disappear regardless of whether the B cells are activated or tolerant. We show genetically that T cell activation, proliferation, and disappearance can be mediated either by transfer of antigen from antigen-specific B cells to endogenous antigen-presenting cells or by direct B-T cell interactions. These results identify a novel antigen presentation route, and demonstrate that B cell presentation of antigen has profound effects on T cell fate that could not be predicted from in vitro studies.

MeSH Terms
Animals Antigen Presentation B-Lymphocytes/immunology Lymphocyte Activation Lymphocyte Cooperation Mice Mice, Transgenic T-Lymphocytes/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Townsend S E
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA.
Goodnow C C
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.187.10.1611
Published
1998-05-18
Pages
1611-21
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2212296
Subset
IM
Grants
NIAID NIH HHS · AI-19512 · United States
NIAID NIH HHS · AI-36535 · United States
External Links
PubMed source DOI: 10.1084/jem.187.10.1611 PMC Full Text View journal details
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