Home LiteratureArticle Details
PMID: 9632605 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Susceptibility to Salmonella typhimurium infection and effectiveness of vaccination in mice deficient in the tumor necrosis factor alpha p55 receptor.

Infection and immunity ·Vol. 66 ·No. 7 ·1998-07-00 ·Pages 3355-64

Everest P, Roberts M, Dougan G

Abstract

Mice defective in the ability to produce the tumor necrosis factor alpha p55 receptor (TNFalphap55R) were orally challenged with a number of Salmonella typhimurium HWSH derivatives that differ in virulence. In comparison to TNFalphap55R+/+ mice, TNFalphap55R-/- mice succumbed earlier to challenge with wild-type S. typhimurium HWSH and S. typhimurium HWSH purE. In contrast, TNFalphap55R-/- mice were able to control an S. typhimurium HWSH aroA challenge, although greater numbers of Salmonella organisms were present in the tissues for a longer time period than was observed with TNFalphap55R+/+ mice. Vaccination of normal and TNFalphap55R knockout animals with S. typhimurium HWSH aroA showed that TNFalphap55R-/- mice, unlike TNFalphap55R+/+ mice, were not protected against a virulent S. typhimurium HWSH challenge. Splenocytes from TNFalphap55R-/- mice exhibited a reduced ability to proliferate in the presence of S. typhimurium antigen compared to TNFalphap55R+/+ mice. Thus, TNFalphap55R is essential for controlling Salmonella growth in tissues and for recall of immunity in murine salmonellosis.

MeSH Terms
Animals Antibodies, Bacterial/blood Colony Count, Microbial Cytokines/biosynthesis Disease Susceptibility Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide/blood Receptors, Tumor Necrosis Factor/deficiency,physiology Salmonella Infections, Animal/immunology,microbiology,pathology Salmonella typhimurium/isolation & purification Vaccination
Chemicals
Antibodies, Bacterial Cytokines Receptors, Tumor Necrosis Factor Nitric Oxide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Everest P
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom.
Roberts M
Dougan G
References (34)
34 references, click to expand
  1. Infection-immunity in experimental salmonellosis.
    J Exp Med. 1966 Oct 1;124(4):601-19 PMID: 5922286
  2. The involvement of tumor necrosis factor in immunity to Salmonella infection.
    J Immunol. 1991 Nov 1;147(9):3161-4 PMID: 1919009
  3. Typhoid fever: pathogenesis and immunologic control. 2.
    N Engl J Med. 1970 Oct 1;283(14):739-46 PMID: 4916916
  4. Vaccines and cell-mediated immunity.
    Bacteriol Rev. 1974 Dec;38(4):371-402 PMID: 4613342
  5. Natural resistance to Salmonella typhimurium in different inbred mouse strains.
    Immunology. 1979 Jun;37(2):311-8 PMID: 381178
  6. Locating salmonella resistance gene on mouse chromosome 1.
    Clin Exp Immunol. 1979 Jul;37(1):1-6 PMID: 385184
  7. Control of early Salmonella typhimurium growth in innately Salmonella-resistant mice does not require functional T lymphocytes.
    J Immunol. 1982 Oct;129(4):1349-51 PMID: 7050243
  8. Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection.
    Infect Immun. 1992 Feb;60(2):450-4 PMID: 1730475
  9. Serum TNF alpha in mouse typhoid and enhancement of a Salmonella infection by anti-TNF alpha antibodies.
    Microb Pathog. 1991 Jul;11(1):33-8 PMID: 1795626
  10. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.
    Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8676-80 PMID: 1528880
  11. Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice.
    Infect Immun. 1993 Feb;61(2):689-98 PMID: 8423095
  12. Proliferative and T-cell specific interleukin (IL-2/IL-4) production responses in spleen cells from mice vaccinated with aroA live attenuated Salmonella vaccines.
    Microb Pathog. 1992 Oct;13(4):305-15 PMID: 1298869
  13. Immunity to intracellular bacteria.
    Annu Rev Immunol. 1993;11:129-63 PMID: 8476559
  14. Role of T cells, TNF alpha and IFN gamma in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro- Salmonella vaccines.
    Microb Pathog. 1992 Dec;13(6):477-91 PMID: 1363824
  15. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.
    Nature. 1993 Aug 26;364(6440):798-802 PMID: 8395024
  16. Bacterial and protozoal infections in genetically disrupted mice.
    Curr Opin Immunol. 1994 Aug;6(4):518-25 PMID: 7946037
  17. Molecular and cellular mechanisms of Salmonella pathogenesis.
    Curr Top Microbiol Immunol. 1994;192:163-85 PMID: 7859505
  18. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.
    Immunity. 1995 Jun;2(6):561-72 PMID: 7540941
  19. Gamma interferon and interleukin-10 gene expression in innately susceptible and resistant mice during the early phase of Salmonella typhimurium infection.
    Infect Immun. 1996 Mar;64(3):849-54 PMID: 8641791
  20. Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location.
    J Immunol. 1996 May 1;156(9):3321-6 PMID: 8617956
  21. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.
    J Exp Med. 1996 Jul 1;184(1):259-64 PMID: 8691140
  22. Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.
    Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23 PMID: 9177215
  23. Immunity to infection with Salmonella typhimurium: mouse-strain differences in vaccine- and serum-mediated protection.
    J Infect Dis. 1984 Sep;150(3):425-35 PMID: 6207248
  24. Production of tumor necrosis factor during murine listeriosis.
    J Immunol. 1987 Dec 15;139(12):4225-31 PMID: 3693903
  25. Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice.
    Infect Immun. 1988 Feb;56(2):419-23 PMID: 3276625
  26. Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex.
    J Immunol. 1988 May 1;140(9):3006-13 PMID: 2834450
  27. Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.
    J Immunol. 1989 Jul 1;143(1):127-30 PMID: 2499625
  28. Cachectin/tumor necrosis factor and other cytokines in infectious disease.
    Curr Opin Immunol. 1989 Feb;1(3):454-61 PMID: 2679705
  29. Evidence that tumor necrosis factor has an important role in antibacterial resistance.
    J Immunol. 1989 Nov 1;143(9):2894-9 PMID: 2509559
  30. Immune responses in BALB/c mice following immunization with aromatic compound or purine-dependent Salmonella typhimurium strains.
    Immunology. 1990 Feb;69(2):184-9 PMID: 2106482
  31. The role of IFN-gamma in murine Salmonella typhimurium infection.
    Microb Pathog. 1990 Feb;8(2):135-41 PMID: 2112220
  32. T cells do not mediate the initial suppression of a Salmonella infection in the RES.
    Immunology. 1990 Jun;70(2):247-50 PMID: 2197215
  33. Killing of Plasmodium falciparum in vitro by nitric oxide derivatives.
    Infect Immun. 1991 Sep;59(9):3280-3 PMID: 1879941
  34. Typhoid fever: pathogenesis and immunologic control.
    N Engl J Med. 1970 Sep 24;283(13):686-91 PMID: 4916913
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.66.7.3355-3364.1998
Published
1998-07-00
Pages
3355-64
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC108352
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1128/IAI.66.7.3355-3364.1998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2