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PMID: 9687419 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Active efflux of norfloxacin by Bacteroides fragilis.

Antimicrobial agents and chemotherapy ·Vol. 42 ·No. 8 ·1998-08-00 ·Pages 2119-21

Miyamae S, Nikaido H, Tanaka Y, Yoshimura F

Abstract

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.

MeSH Terms
Anti-Infective Agents/pharmacokinetics Bacterial Proteins/physiology Bacteroides fragilis/drug effects,metabolism Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology Carrier Proteins/physiology Drug Resistance, Microbial Membrane Transport Proteins Microbial Sensitivity Tests Norfloxacin/pharmacokinetics,pharmacology
Chemicals
Anti-Infective Agents Bacterial Proteins Carrier Proteins Membrane Transport Proteins Bmr protein, Bacillus subtilis Carbonyl Cyanide m-Chlorophenyl Hydrazone Norfloxacin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Miyamae S
Department of Microbiology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.
Nikaido H
Tanaka Y
Yoshimura F
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.42.8.2119
Published
1998-08-00
Pages
2119-21
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC105880
Subset
IM
Grants
NIAID NIH HHS · R01 AI009644 · United States
NIAID NIH HHS · R37 AI009644 · United States
NIAID NIH HHS · AI-09644 · United States
External Links
PubMed source DOI: 10.1128/AAC.42.8.2119 PMC Full Text View journal details
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