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PMID: 9705398 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Intercontinental spread of a multidrug-resistant methicillin-resistant Staphylococcus aureus clone.

Journal of clinical microbiology ·Vol. 36 ·No. 9 ·1998-09-00 ·Pages 2590-6

Aires de Sousa M, Sanches IS, Ferro ML, Vaz MJ, Saraiva Z, Tendeiro T, Serra J, de Lencastre H

Abstract

Two hundred ten methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered between 1990 and 1997 from three Portuguese hospitals located in Lisbon and Oporto were analyzed by molecular fingerprinting techniques. The hybridization of ClaI restriction digests with the mecA- and Tn554-specific DNA probes combined with pulsed-field gel electrophoresis documented the abrupt appearance and extensive intrahospital spread of the Brazilian epidemic MRSA clone in the 1995 samples of each one of the three hospitals analyzed-suggesting the intercontinental transfer of this strain from Brazil to Portugal. The appearance of this clone may challenge the dominance of another highly epidemic imported clone-the Iberian MRSA, currently the most widely spread MRSA clone in Portuguese hospitals.

MeSH Terms
Brazil DNA Primers Drug Resistance, Multiple Genes, Bacterial Humans Methicillin Resistance Polymorphism, Genetic Portugal Random Amplified Polymorphic DNA Technique Spain Staphylococcal Infections/classification,transmission Staphylococcus aureus/drug effects,genetics
Chemicals
DNA Primers
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Aires de Sousa M
Unidade de Genética Molecular, Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa (ITQB/UNL), Oeiras, Lisbon, Portugal.
Sanches I S
Ferro M L
Vaz M J
Saraiva Z
Tendeiro T
Serra J
de Lencastre H
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/JCM.36.9.2590-2596.1998
Published
1998-09-00
Pages
2590-6
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC105168
Subset
IM
External Links
PubMed source DOI: 10.1128/JCM.36.9.2590-2596.1998 PMC Full Text View journal details
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