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Therapeutic potential of spleen tyrosine kinase inhibition for treatment of hig…

Samples:9 Organism:Mus musculus Type:transcription profiling by array March 29, 2014

...SYK) signaling in vivo. In diagnostic samples from human B-ALL patients, SYK and downstream targets were phosphorylated ...

Dectin-1-mediated signaling leads to characteristic gene expressions in rat mas…

Samples:6 Organism:Rattus norvegicus Type:transcription profiling by array March 27, 2014

...Syk inhibitor R406-pretreated cells in order to examine the importance of Syk for Dectin-1-mediated gene up-regulations.

SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia

Samples:20 Organism:Homo sapiens Type:transcription profiling by array Jan. 15, 2014

...SYK-directed shRNAs: shSYK_1 (clone ID TRCN0000197257, target sequence GCAGCAGAACAGACATGTCAA) and shSYK_2 (clone I...

Gene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lin…

Samples:29 Organism:Homo sapiens Type:transcription profiling by array Dec. 31, 2013

...SYK 525/526 and SYK-dependent phosphorylation of BCR signaling components such as BLNK. RNA samples from two DLBCL cell ...

Gene expression profiling of five diffuse large B-cell lymphoma (DLBCL) cell li…

Samples:75 Organism:Homo sapiens Type:transcription profiling by array Aug. 31, 2013

...SYK 525/526 and SYK-dependent phosphorylation of BCR signaling components such as BLNK. RNA samples from five DLBCL cell...

HGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and …

Samples:8 Organism:Mus musculus Type:transcription profiling by array May 22, 2013

Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-typ...

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on…

Samples:8 Organism:Mus musculus Type:transcription profiling by array April 24, 2013

...Syk as a critical mediator of Itgb3 activity in leukemia. Finally, we confirmed that Itgb3 is dispensable for normal hem...

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on…

Samples:24 Organism:Homo sapiens Type:transcription profiling by array April 24, 2013

...Syk.  In contrast, loss of Itgb3 in normal HSPCs did not affect engraftment, reconstitution, or differentiation.  Finall...

A macrophage autonomous α4β1integrin-Syk-Rac2 signaling axis controls macrophag…

Samples:12 Organism:Mus musculus Type:transcription profiling by array Nov. 15, 2012

...Syk-Rac2 signaling axis acts in concert with the p110 isoform (PTEN-PI-3 kinase pathway) to control metastasis. SmoA1 Tg...

A macrophage autonomous alpha4beta1integrin-Syk-Rac2 signaling axis controls ma…

Samples:10 Organism:Mus musculus Type:transcription profiling by array Oct. 2, 2012

...Syk-Rac2 signaling axis acts in concert with the p110 isoform (PTEN-PI-3 kinase pathway) to control metastasis. Bone mar...

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