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Integrated genomic analysis illustrates the central role of JAK-STAT pathway ...

样本量:12 物种:Homo sapiens 类型:transcription profiling by array 2014年6月3日

...JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identi...

Integrated genomic analysis illustrates the central role of JAK-STAT pathway ...

样本量:104 物种:Homo sapiens 类型:transcription profiling by array 2014年6月3日

...JAK2-mutant MPN patients consistent with a shared mechanism of transformation by JAK2 and CALR mutations. We also identi...

Triplication of a 21q22 region contributes to B cell transformation through H...

样本量:8 物种:Mus musculus 类型:ChIP-seq 2014年4月20日

...JAK2. Chr.21q22 triplication suppresses H3K27me3 in murine progenitor B cells and B-ALLs, and ÒbivalentÓ genes with both...

Triplication of a 21q22 region contributes to B cell transformation through H...

样本量:8 物种:Mus musculus 类型:transcription profiling by array 2014年4月20日

...JAK2. Chr.21q22 triplication suppresses H3K27me3 in murine progenitor B cells and B-ALLs, and “bivalent” genes with both...

Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is e...

样本量:4 物种:Mus musculus 类型:transcription profiling by array 2014年3月12日

...JAK2) gene in HSCs that renders this kinase constitutively active, leading to uncontrolled cell expansion. The bone marr...

Neuropathy of the haematopoietic stem cell niche is essential for myeloprolif...

样本量:2 物种:Mus musculus 类型:RNA-seq of coding RNA 2014年3月12日

...JAK2) gene in HSCs that renders this kinase constitutively active, leading to uncontrolled cell expansion. The bone marr...

Constitutively active STAT5 recruits p53 to alternative transcriptional targe...

样本量:8 物种:Homo sapiens 类型:ChIP-chip by tiling array 2014年2月1日

...JAK2 inhibition (ruxolitinib) to inhibit STAT5 phosphorylation and DNA binding.

IL6 Related Cytokines Augment Angiogenesis in Nascent and Mature Human Endoth...

样本量:7 物种:Homo sapiens 类型:transcription profiling by array 2013年12月14日

...JAK2 inhibition. Furthermore, we found evidence of JAK2 dependent cytokine signaling in more mature endothelium, highlig...

Murine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F...

样本量:2 物种:Mus musculus 类型:transcription profiling by array 2013年10月31日

...JAK2 V617F mutant comparing control Ba/F3 cells expressing wild type JAK2. Two-condition experiment, WT cells vs. VF cel...

TEL-JAK2 dependent transcriptome

样本量:12 物种:Mus musculus 类型:transcription profiling by array 2013年9月28日

...JAK2 tyrosine kinase. Mice carrying a TEL-JAK2 transgene develop T-ALL. Gene deregulated in TEL-JAK2 T-ALL cells as comp...

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