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Unanchored by two hits: IFNγ and mechanical stress synergize to undermine mel...

Lee(EJ),Kwon(IJ),Kim(JY),Park(S),Han(HT),H... Br J Dermatol 2026-03-31

...CTSL)-dependent mechanism. IFNγ and mechanical stress contribute to melanocyte detachment from the basement membrane via...

Regional immunosuppression and associated systemic markers in focally relapse...

Ollila(H),Kulkarni(P),Kim(H),Ankola(P),Chi... J Immunother Cancer 2026-04-15

...CTSL), and CTL-suppression (ARG1, PLA2G7) pathways. Our analyses revealed that regional immunosuppression mediated by ad...

Cathepsin G Promotes Hepatic Lipid Deposition by Regulating Key Genes Related...

Yang(W),Lin(J),Pan(Q),Jiang(Y),Shi(T),Cao(... FASEB J 2026-04-30

...CTSL were consistently highly expressed across all samples. Notably, steatosis patients and diabetic mice exhibited sign...

Pinostrobin attenuates microglia-mediated neuroinflammation after subarachnoi...

Liu(Q),Wang(Y),Wang(B),Yang(D),Wang(J),Ou(... Naunyn Schmiedebergs Arch P... 2026-05-00

...CTSL were identified as candidate targets potentially linking PIN to SAH-related inflammatory pathways. Molecular dockin...

Bisphenol S exposure before sexual maturity impairs follicular development vi...

Li(F),Shen(F),Zhou(Y),Zheng(Y),Tian(J),Li(... Ecotoxicol Environ Saf 2026-03-15

...CTSL, CTSD, and CTSB), thereby activating the caspase 3 apoptotic pathway. CTSL knockdown further confirmed its critical...

TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation...

Khan(S),Yan(F),Li(W),Guo(J),Gu(X),Tang(Z),... J Transl Med 2026-03-17

...CTSL, HEXB, and GM2A. Rapamycin-mediated activation of autophagy resulted in partial but significant developmental rescu...

Gene Expression Profiling of SARS-CoV-2 Host Entry Factors in Nasal and Oral ...

Al Nemer(F),Skafi(N),Fayyad-Kazan(H),Fakhr... Curr Microbiol 2026-02-19

SARS-CoV-2 entry into host cells relies on key proteins like ACE2, TMPRSS2, FURIN, and CTSL, yet data remain limited reg...

Characterization of Lysosomal Hydrolases and Transporters and Their Age-Depen...

Gadara(D),Singh(DK),Subash(S),Yue(G),Ahire... Clin Pharmacol Ther 2026-05-26

...CTSL, NAGLU, PLD3, and GALNS) and transporters (ATP6V1B2, ATP6V1C1, TMEM63A, and SLC39A14). Together, these findings hig...

Cannabichromeorcin targets cathepsin L to alleviate oxidative stress-Driven a...

Huang(J),Chen(Y),Deng(Y),Hu(D),Chen(Y),Li(... Redox Biol 2026-07-00

...CTSL) as a redox-sensitive pharmacological target of CBCO. Pretreatment with CBCO inhibited CTSL, thereby reducing the f...

Cathepsins are involved in ovarian remodeling post-parturition in black rockf...

Liu(J),Zuo(C),Jing(X),Zhang(X),Niu(C),Liu(... Gen Comp Endocrinol 2026-06-00

...CTSL) have been implicated in uterine remodeling, follicle atrophy, and granulosa cell apoptosis in various vertebrates....

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