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CD74-Targeted Cathepsin-Inhibitor Antibody-Drug Conjugate Triggers Apoptosis ...

Abd-Elrahman(I),Khairi(N),Sinai-Turyansky(... Cells 2026-02-04

...CTSL+ DLBCL subgroup. This is the first study demonstrating coordinated overexpression of CD74 and CTSL and proposing th...

Interferon-gamma-inducible protein 30 prevents IFN-γ-receptor 1 degradation t...

Mizuno(S),Mizuno(Y),Abe(K),Macy(AM),Chong(... Cell Commun Signal 2026-02-12

...CTSL), and modulating IFN-γ pathway signaling. Briefly, IFI30, PD-L1, MHC-II and CTSL levels are stimulated by IFN-γ in ...

Design and optimization of N-(3-((4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pheny...

Wang(Z),Mao(Z),Shen(C),Wang(R),Liu(B),Zhan... Eur J Med Chem 2026-04-05

...CTSL) inhibitors to reduce the expression of pro-inflammatory cytokines. Among these compounds, B5 exhibited dose-depend...

Gene Expression Profiling of SARS-CoV-2 Host Entry Factors in Nasal and Oral ...

Al Nemer(F),Skafi(N),Fayyad-Kazan(H),Fakhr... Curr Microbiol 2026-02-19

SARS-CoV-2 entry into host cells relies on key proteins like ACE2, TMPRSS2, FURIN, and CTSL, yet data remain limited reg...

Characterization of Lysosomal Hydrolases and Transporters and Their Age-Depen...

Gadara(D),Singh(DK),Subash(S),Yue(G),Ahire... Clin Pharmacol Ther 2026-05-26

...CTSL, NAGLU, PLD3, and GALNS) and transporters (ATP6V1B2, ATP6V1C1, TMEM63A, and SLC39A14). Together, these findings hig...

TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation...

Khan(S),Yan(F),Li(W),Guo(J),Gu(X),Tang(Z),... J Transl Med 2026-03-17

...CTSL, HEXB, and GM2A. Rapamycin-mediated activation of autophagy resulted in partial but significant developmental rescu...

Cannabichromeorcin targets cathepsin L to alleviate oxidative stress-Driven a...

Huang(J),Chen(Y),Deng(Y),Hu(D),Chen(Y),Li(... Redox Biol 2026-07-00

...CTSL) as a redox-sensitive pharmacological target of CBCO. Pretreatment with CBCO inhibited CTSL, thereby reducing the f...

Evolutionary Signatures of Thermotolerance Shaped by Adaptive Admixtures in t...

Goli(RC),Chishi(KG),Sruthi(OS),Gunturu(T),... J Mol Evol 2026-07-24

...CTSL, and HSPA14 contributed to environmental adaptability, whereas ATP11A influenced lean meat yield. A 1000 SNP ancest...

Long-Read Single-Cell RNA Sequencing Reveals Dynamic Isoform Changes During C...

Ou(LC),Zhou(M),Chen(H),Huang(ZB),Yang(YX),... Invest Ophthalmol Vis Sci 2026-09-01

...CTSL) showed altered isoform usage despite relatively stable total expression. ARID5B and GSN exhibited cell-type-specif...

Evolutionary diversification and immunoprofiling of cathepsin L toolkit in co...

Nayak(S),Kyslík(J),Majstorović(J),Dobai(T)... Front Cell Infect Microbiol None

...ctsl.1A/B are enriched at mucosal barriers, whereas ctslaA/B predominate in metabolic and systemic immune hubs and are t...

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