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A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 ...

Zhou(D),Zhang(Y),Yang(Z),Zhang(C),Zhang(Q)... Sci Adv 2026-01-16

...DOC2A∆Val217-Pro218 and DOC2AFull-Length, and interactome profiling highlighted that DOC2A∆Val217-Pro218 unique interact...

Integrative multi-omics identifies DOC2A as a novel pharmacological target fo...

Yuan(C),Zhang(B),Liang(Y),Ran(J),Hu(S),Liu... Psychol Med 2026-05-28

...DOC2A emerging as the top candidate. Colocalization (H4 > 0.8) and SMR supported a causal association of DOC2A with BD, ...

Cellular insights into transposable elements in Alzheimer's disease.

Kumar(V),Beck(S) Front Mol Biosci None

...DOC2A, ABCA7, PTK2B, IL34, ABCB9, PLD3, and TARDBP. These findings highlight cell-type-specific TE activation in AD and ...

Lysosome-derived biomarkers for predicting survival outcome in acute myeloid ...

Li(G),Miao(Y),Yuan(F),Zhang(W),Wu(Y),Zhu(L... Discov Oncol 2025-08-02

...DOC2A, CHMP4C, and SLC29A3), which categorized AML patients into two groups with significant survival and tumor microenv...

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glu...

Li(Jia),Cantley(James),Burchfield(James G)... Diabetologia 2015-07-06

...Doc2a (-/-) (Doc2aKO), Doc2b (-/-) (Doc2bKO) and Doc2a (-/-)/Doc2b (-/-) (Doc2a/Doc2bKO) mice in vivo. In vitro GSIS and...

Strong synaptic transmission impact by copy number variations in schizophreni...

Glessner(Joseph T),Reilly(Muredach P),Kim(... Proc Natl Acad Sci U S A 2010-07-19

...DOC2A, both calcium-signaling genes responsible for neuronal excitation, were deleted in 16 cases and duplicated in 10 c...

Duplication 16p11.2 in a child with infantile seizure disorder.

Bedoyan(Jirair K),Kumar(Ravinesh A),Sudi(J... Am J Med Genet A 2010-08-30

...DOC2A, QPRT, and SEZ6L2, genes within the duplicated 16p11.2 region that have been implicated in neuronal function and/o...

O-C2 angle as a predictor of dyspnea and/or dysphagia after occipitocervical ...

Miyata(Masahiko),Neo(Masashi),Fujibayashi(... Spine (Phila Pa 1976) 2009-04-09

...dOC2A and % dS were significantly lower in group A than in group B. All patients with dOC2A of less than -10 degrees sho...

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-depende...

Groffen(Alexander J A),Friedrich(Reut),Bri... J Neurochem 2006-06-22

...DOC2A and DOC2B are modulated by submicromolar calcium levels. Fluorescent-tagged DOC2A and DOC2B translocated to plasma...

Different spatiotemporal expression of DOC2 genes in the developing rat brain...

Korteweg(N),Denekamp(F A),Verhage(M),Burba... Eur J Neurosci 2000-03-16

DOC2A and DOC2B are two homologous genes implicated in synaptic vesicle exocytosis. Their complementary, nonoverlapping ...

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