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Integrative multi-omics identifies DOC2A as a novel pharmacological target fo...

Yuan(C),Zhang(B),Liang(Y),Ran(J),Hu(S),Liu... Psychol Med 2026-05-28

...DOC2A emerging as the top candidate. Colocalization (H4 > 0.8) and SMR supported a causal association of DOC2A with BD, ...

A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 ...

Zhou(D),Zhang(Y),Yang(Z),Zhang(C),Zhang(Q)... Sci Adv 2026-01-16

...DOC2A∆Val217-Pro218 and DOC2AFull-Length, and interactome profiling highlighted that DOC2A∆Val217-Pro218 unique interact...

Cellular insights into transposable elements in Alzheimer's disease.

Kumar(V),Beck(S) Front Mol Biosci None

...DOC2A, ABCA7, PTK2B, IL34, ABCB9, PLD3, and TARDBP. These findings highlight cell-type-specific TE activation in AD and ...

Lysosome-derived biomarkers for predicting survival outcome in acute myeloid ...

Li(G),Miao(Y),Yuan(F),Zhang(W),Wu(Y),Zhu(L... Discov Oncol 2025-08-02

...DOC2A, CHMP4C, and SLC29A3), which categorized AML patients into two groups with significant survival and tumor microenv...

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glu...

Li(Jia),Cantley(James),Burchfield(James G)... Diabetologia 2015-07-06

...Doc2a (-/-) (Doc2aKO), Doc2b (-/-) (Doc2bKO) and Doc2a (-/-)/Doc2b (-/-) (Doc2a/Doc2bKO) mice in vivo. In vitro GSIS and...

Strong synaptic transmission impact by copy number variations in schizophreni...

Glessner(Joseph T),Reilly(Muredach P),Kim(... Proc Natl Acad Sci U S A 2010-07-19

...DOC2A, both calcium-signaling genes responsible for neuronal excitation, were deleted in 16 cases and duplicated in 10 c...

Duplication 16p11.2 in a child with infantile seizure disorder.

Bedoyan(Jirair K),Kumar(Ravinesh A),Sudi(J... Am J Med Genet A 2010-08-30

...DOC2A, QPRT, and SEZ6L2, genes within the duplicated 16p11.2 region that have been implicated in neuronal function and/o...

O-C2 angle as a predictor of dyspnea and/or dysphagia after occipitocervical ...

Miyata(Masahiko),Neo(Masashi),Fujibayashi(... Spine (Phila Pa 1976) 2009-04-09

...dOC2A and % dS were significantly lower in group A than in group B. All patients with dOC2A of less than -10 degrees sho...

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-depende...

Groffen(Alexander J A),Friedrich(Reut),Bri... J Neurochem 2006-06-22

...DOC2A and DOC2B are modulated by submicromolar calcium levels. Fluorescent-tagged DOC2A and DOC2B translocated to plasma...

Different spatiotemporal expression of DOC2 genes in the developing rat brain...

Korteweg(N),Denekamp(F A),Verhage(M),Burba... Eur J Neurosci 2000-03-16

DOC2A and DOC2B are two homologous genes implicated in synaptic vesicle exocytosis. Their complementary, nonoverlapping ...

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