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Investigating the role of EFhd2 protein in modulating tau pathology in a tauo...

Soliman(AS),Umstead(A),Vega(IE) Front Mol Neurosci None

...Efhd2 deletion in Tau P301L mice. Independent of p-values, Efhd2 deletion also showed a medium-to-large main effect in r...

Mapping the function of EF-hand domain-containing protein 2 and determining i...

Luo(X),Zhang(F),Li(Z),Zhong(C),Shen(X) Cytojournal None

...EFHD2 and assess immune cell infiltration in clinical samples. To further investigate the functional effect of EFHD2, we...

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMG...

Yu(Y),Wu(H),Xiao(Y),Qiu(J),Hong(L),Yang(B)... Cell Death Dis 2026-06-23

...EFHD2 being essential for its DNA repair function. Elevated EFHD2-driven lactate reshaped the tumor immune microenvironm...

[Preliminary study on the biological role of EF-hand domain-containing protei...

Zhang(YM),Li(X),Jia(XX),Liu(JZ),Li(WQ),Xua... Zhonghua Yu Fang Yi Xue Za Zhi 2025-08-06

...EFHD2 demonstrated significant upregulation in HCC tissues versus normal controls (P<0.05). Elevated EFHD2 expression co...

Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho f...

Huh(Yun Hyun),Oh(Sena),Yeo(Yu Ra),Chae(In ... Oncotarget 2016-04-12

...EFHD2), enhanced motile protrusions associated with actin, such as lamellipodia and membrane ruffles. Swiprosin-1 levels...

EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders.

Vega(Irving E) Front Neurosci 2016-04-12

EFhd2 is a conserved calcium binding protein linked to different neurological disorders and types of cancer. Although, E...

The calcium-binding protein EFhd2 modulates synapse formation in vitro and is...

Borger(Eva),Herrmann(Abigail),Mann(David A... J Neuropathol Exp Neurol 2015-01-26

...EFhd2 expression in cultured cortical neurons, we demonstrate that loss of EFhd2 affects the number of synapses develope...

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved...

Purohit(Pavitra),Perez-Branguli(Francesc),... PLoS One 2015-05-12

...EFhd2 (EFhd2) is a cytoskeletal Ca2+ sensor protein strongly expressed in the brain. It has been shown to interact with ...

Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunit...

Brachs(Sebastian),Turqueti-Neves(Adriana),... Eur J Immunol 2015-03-03

...EFhd2 (EFhd2) can promote apoptosis in activated B cells. We therefore hypothesized that EFhd2 might limit humoral immun...

Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity.

Vázquez-Rosa(Edwin),Rodríguez-Cruz(Eva N),... Protein Sci 2015-04-19

...EFhd2 may be phosphorylated. Here, we determine whether Cdk5, a hyperactivated kinase in tauopathies, phosphorylates EFh...

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