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Mapping the function of EF-hand domain-containing protein 2 and determining i...

Luo(X),Zhang(F),Li(Z),Zhong(C),Shen(X) Cytojournal None

...EFHD2 and assess immune cell infiltration in clinical samples. To further investigate the functional effect of EFHD2, we...

Investigating the role of EFhd2 protein in modulating tau pathology in a tauo...

Soliman(AS),Umstead(A),Vega(IE) Front Mol Neurosci None

...Efhd2 deletion in Tau P301L mice. Independent of p-values, Efhd2 deletion also showed a medium-to-large main effect in r...

EFHD2 drives lactate-mediated DNA damage repair and immunosuppression via HMG...

Yu(Y),Wu(H),Xiao(Y),Qiu(J),Hong(L),Yang(B)... Cell Death Dis 2026-06-23

...EFHD2 being essential for its DNA repair function. Elevated EFHD2-driven lactate reshaped the tumor immune microenvironm...

[Preliminary study on the biological role of EF-hand domain-containing protei...

Zhang(YM),Li(X),Jia(XX),Liu(JZ),Li(WQ),Xua... Zhonghua Yu Fang Yi Xue Za Zhi 2025-08-06

...EFHD2 demonstrated significant upregulation in HCC tissues versus normal controls (P<0.05). Elevated EFHD2 expression co...

Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho f...

Huh(Yun Hyun),Oh(Sena),Yeo(Yu Ra),Chae(In ... Oncotarget 2016-04-12

...EFHD2), enhanced motile protrusions associated with actin, such as lamellipodia and membrane ruffles. Swiprosin-1 levels...

EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders.

Vega(Irving E) Front Neurosci 2016-04-12

EFhd2 is a conserved calcium binding protein linked to different neurological disorders and types of cancer. Although, E...

Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity.

Vázquez-Rosa(Edwin),Rodríguez-Cruz(Eva N),... Protein Sci 2015-04-19

...EFhd2 may be phosphorylated. Here, we determine whether Cdk5, a hyperactivated kinase in tauopathies, phosphorylates EFh...

Swiprosin-1/EFhd2 limits germinal center responses and humoral type 2 immunit...

Brachs(Sebastian),Turqueti-Neves(Adriana),... Eur J Immunol 2015-03-03

...EFhd2 (EFhd2) can promote apoptosis in activated B cells. We therefore hypothesized that EFhd2 might limit humoral immun...

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved...

Purohit(Pavitra),Perez-Branguli(Francesc),... PLoS One 2015-05-12

...EFhd2 (EFhd2) is a cytoskeletal Ca2+ sensor protein strongly expressed in the brain. It has been shown to interact with ...

The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in...

Morowski(Martina),Brachs(Sebastian),Mielen... PLoS One 2015-06-16

...EFhd2 in immune cells, we tested the hypothesis that EFhd2 is a crucial adaptor protein for platelet function acting as ...

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