Literature Search

Stansley(B),Islam(MM),Aguiar(DJ),Fuchs(Z),Ca… Epilepsia 2026-07-00

...Tsc1 conditional knockout (cKO) mice treated with simufilam or vehicle twice daily (BID). Simufilam plasma concentration...

Yan(T),Zheng(X),Jia(G),Liang(Z),Guo(L),Ding(… J Hazard Mater 2026-05-15

...TSC1/2-mTOR signaling while concurrently weakening the Akt-TSC1/2-mTOR axis, a pathway shift validated by specific inhib...

Farach(LS),Leu(C),Lal(D),Smith(AR),Montanucc… Genet Med 2026-06-00

...TSC1/TSC2 may be warranted, especially as the diagnosis of TSC could mask these second neurodevelopmental disorders and ...

Han(MH),Chu(J),Wang(Y),Guo(ZH),Liu(Y),Yu(WJ)… Zhonghua Bing Li Xue Za Zhi 2026-04-08

...TSC1 mutations in 2 cases. Follow-up of the cases ranged from 6 to 159 months. All patients were alive at the end of the...

Del Baldo(G),Milano(GM),Salvatore(MD),Mastro… Oncologist 2026-06-06

...TSC1 or TSC2 genes, resulting in constitutive mTOR signaling pathway activation, a central driver of tumorigenesis and a...

Lei(X),Lang(T),Li(P),Wu(C) Int J Mol Sci 2026-03-27

...Tsc1+/- and Tsc2+/- MEFs. Mechanistically, Tsc1 or Tsc2 deletion reduced global H3K27me3, correlating with increased via...

Winden(K),Bebin(EM),Jeste(S),Krueger(DA),Pau… Nat Rev Dis Primers 2026-03-12

...TSC1 and TSC2 and the mechanistic target of rapamycin (mTOR) signalling pathway. TSC1 and TSC2 form a protein complex th...

Reid(L),Ganapathiraju(S),Mancinelli(S),Kagan… bioRxiv 2026-03-05

...TSC1 are unlikely to arise from RORγ-expressing immune cell-dependent mechanisms but instead reflect direct neuronal los...

Houssaini(A),Marcos(E),Gros(V),Born(E),Abid(… Sci Rep 2026-03-17

...TSC1, a negative regulator of the mTOR complex 1, in fibroblasts (SM22-TSC1–/– mice), endothelial cells (PDGF-TSC1–/– mi...

Raman(R),Maharjan(D),Dehner(C),Segura(S) Case Rep Pathol None

...TSC1 variant, leading to a definite diagnosis of uterine PEComa with lymphangioleiomyomatosis (LAM)-like features. The p...