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Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disea…

Liu(Y),Tao(J),Tan(D),Zheng(F),Su(Z),Yuan(J),… Research (Wash D C) None

...SYK/SH3BP2 signaling pathway as the crucial mechanism driving MASLD pathogenesis. PF effectively attenuated hepatic meta...

Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation an…

Jansen(M),Strub(JM),Chaloin(L),Coopman(P),Be… Life Sci Alliance 2026-04-00

...Syk-Cys by the DHHC5 enzyme that specifically associates with Syk upon phagocytosis. Syk palmitoylation is important for...

Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruct…

Guo(J),Qiu(Q),Yan(X),Zhang(Z),Zhang(X),An(N)… Int J Oral Sci 2026-02-05

...Syk). In vivo, Pg EVs exacerbated RA-induced bone destruction by activating Syk-dependent osteoclastogenesis. R406, a Sy...

The THP-1 cell line as a model for the assessment of monoclonal antibodies aggr…

Lteif(M),Abratanska(S),Turbica(I),Pallardy(M) Eur J Pharm Biopharm 2026-04-00

...Syk pathway and to activate Syk in a Src-dependent manner. ERK kinase was also activated. Taken together, our results hi...

A viral glycoprotein targets IgG+ memory B cells to mediate humoral immune evas…

Cramer(P),Neys(SFH),Fiedler(M),Lorenzetti(R)… EMBO Mol Med 2026-02-00

...SYK-independent manner. Prolonged stimulation also induces B-cell activation via upregulation of CD69 and CD86. In a T-c...

Compromised hepatic bilirubin clearance drives depressive symptoms via regulati…

Sun(S),Li(M),Ma(J),He(K),Wang(L),Li(C),Liu(X… J Neuroinflammation 2026-01-20

...SYK conditional knockouts), we combined behavioral assays, multi-omics, electrophysiology, and optogenetics to explore t...

Acetyl tributyl citrate as a new risk factor for osteoporosis: An integrated st…

Qin(S),Li(L),Tang(G),Mu(Y),Deng(Z) Ecotoxicol Environ Saf 2026-01-15

...SYK, BRD4, PTK2B, ADAMTS5), which demonstrated strong binding affinity with ATBC in molecular docking and exhibited stab...

Immune thrombocytopenia in patients with connective tissue disease.

Liu(K),Zheng(Z),Chen(S),Liu(Y),Zhang(G),He(T) Clin Rheumatol 2026-03-00

...Syk) and Bruton's tyrosine kinase (BTK) inhibitors, as well as neonatal Fc receptor (FcRn) inhibitors, have shown consid...

Unveiling the gut-brain axis: How chronic exposure to arsenic-induced microglia…

Qu(J),Jiang(X),Ma(Y),Sheng(X),Pi(C),Wang(Y),… J Hazard Mater 2026-02-01

...SYK and CD36). Furthermore, SiAhR treatment could alleviated microglial inflammatory injury and enhancing the microglia'...

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B…

Vatovec(T),Neehus(AL),Jackson(KJL),Avery(DT)… Nat Immunol 2026-02-00

...SYK ubiquitination and B cell receptor signaling. Here we studied individuals with somatically homozygous CBL loss-of-fu...

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