...SYK/SH3BP2 signaling pathway as the crucial mechanism driving MASLD pathogenesis. PF effectively attenuated hepatic meta...
...Syk-Cys by the DHHC5 enzyme that specifically associates with Syk upon phagocytosis. Syk palmitoylation is important for...
...Syk). In vivo, Pg EVs exacerbated RA-induced bone destruction by activating Syk-dependent osteoclastogenesis. R406, a Sy...
...Syk pathway and to activate Syk in a Src-dependent manner. ERK kinase was also activated. Taken together, our results hi...
...SYK-independent manner. Prolonged stimulation also induces B-cell activation via upregulation of CD69 and CD86. In a T-c...
...SYK conditional knockouts), we combined behavioral assays, multi-omics, electrophysiology, and optogenetics to explore t...
...SYK, BRD4, PTK2B, ADAMTS5), which demonstrated strong binding affinity with ATBC in molecular docking and exhibited stab...
...Syk) and Bruton's tyrosine kinase (BTK) inhibitors, as well as neonatal Fc receptor (FcRn) inhibitors, have shown consid...
...SYK and CD36). Furthermore, SiAhR treatment could alleviated microglial inflammatory injury and enhancing the microglia'...
...SYK ubiquitination and B cell receptor signaling. Here we studied individuals with somatically homozygous CBL loss-of-fu...
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