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The rho exchange factors vav2 and vav3 control a lung metastasis-specific trans…

Citterio(Carmen),Menacho-Márquez(Mauricio),G… Sci Signal 2013-03-04

...Vav2 and Vav3, play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and many of the step...

Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-ca…

Valls(Gabriela),Codina(Montserrat),Miller(Ra… J Cell Sci 2013-07-16

...Vav2. Vav2 and Rac1 association with p120-catenin was modulated by phosphorylation of this protein, which was stimulated...

Identification and structural basis for a novel interaction between Vav2 and Ar…

Wu(Bo),Wang(Fengsong),Zhang(Jiahai),Zhang(Zh… J Struct Biol 2013-02-21

...Vav2 both in vitro and in vivo. ITC and NMR chemical shift perturbation experiments demonstrated that Vav2 SH2 domain wa...

The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyr…

Emami-Nemini(Alexander),Gohla(Antje),Urlaub(… Mol Pharmacol 2012-10-09

...vav2, a guanine nucleotide exchange factor (GEF) for Rho GTPases, as a PTHR-interacting protein. The core domains of vav...

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signali…

Kajla(Seheli),Mondol(Abdus S),Nagasawa(Atsus… FASEB J 2012-06-29

...Vav2 by Src-mediated tyrosine phosphorylation. Nox1-generated ROS oxidize and inactivate NRX, thereby releasing the NRX-...

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, prol…

Chang(Kyung Hee),Sanchez-Aguilera(Abel),Shen… Blood 2012-10-09

...Vav2-deficient B-cell progenitors increases the transformation ability of p190-BCR-ABL. Vav3 deficiency induces apoptosi...

IbeA and OmpA of Escherichia coli K1 exploit Rac1 activation for invasion of hu…

Maruvada(Ravi),Kim(Kwang Sik) Infect Immun 2012-07-17

...Vav2, not β-Pix, was involved in E. coli K1-mediated Rac1 activation. Since activated STAT3 is known to bind GTP-Rac1, t...

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.

Montalvo-Ortiz(Brenda L),Castillo-Pichardo(L… J Biol Chem 2012-06-19

...Vav2, EHop-016 inhibits the association of Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activat...

The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of…

Krause-Gruszczynska(Malgorzata),Boehm(Manja)… Cell Commun Signal 2012-10-02

...Vav2 is required for Cdc42 activation and maximal bacterial invasion. Overexpression of certain mutant constructs indica...

Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in pla…

Fukumoto(Yuri),Kurita(Souichi),Takai(Yoshimi… J Biol Chem 2012-03-27

...Vav2, a GDP/GTP exchange factor for Rac, in a Src phosphorylation-dependent manner, suggesting that ADIP mediates the ac...

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