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The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lys...

Meenhuis(Annemarie),Verwijmeren(Carola),Ro... Biochem J 2011-04-19

...SOCS3 (suppressor of cytokine signalling 3) has been shown to play a major role in this process. Deubiquitinating enzyme...

Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the ...

Lin(Yu-Ching),Lin(Chin-Kuo),Tsai(Ying-Huan... Oncol Rep 2011-02-24

...SOCS3 expression induced apoptosis of NSCLC cells that did not express SOCS3. In addition, overexpression of SOCS3 by ad...

Suppression of SOCS3 increases susceptibility of renal cell carcinoma to inte...

Tomita(Shintaro),Ishibashi(Kei),Hashimoto(... Cancer Sci 2011-01-18

...SOCS3-targeted siRNA on 786-O xenografts were determined by SOCS3 expression, morphological observation, and tumor volum...

Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling.

Jia(Danlin),Rahbar(Ramtin),Chan(Renee W Y)... PLoS One 2011-04-27

...SOCS3. By contrast, treatment of ex vivo human lung tissues with IFN-α results in the up-regulation of a number of IFN-s...

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.

Yang(Jinbo),Huang(Jing),Dasgupta(Maupali),... Proc Natl Acad Sci U S A 2011-05-12

...SOCS3) but not all (i.e., CD14) STAT3 target genes. Biological relevance is shown by the observation that overexpression...

IL-27 increases the proliferation and effector functions of human naïve CD8+ ...

Schneider(Raphael),Yaneva(Teodora),Beausei... Eur J Immunol 2011-01-31

...SOCS3 expression in a STAT1-dependent manner by human CD8(+) T cells. Addition of IL-27 to α-CD3-activated naïve CD8(+) ...

Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primar...

Raia(Valentina),Schilling(Marcel),Böhm(Mar... Cancer Res 2011-05-02

...SOCS3 are upregulated within 2 hours in MedB-1 but not in L1236 cells. On the basis of this detailed quantitative inform...

[Expression of suppressor of cytokine signaling 3 and its significance in hum...

Zhang(Li-juan),Li(Ming-yue) Zhonghua Fu Chan Ke Za Zhi 2011-08-15

...SOCS3 may participate in the pathogenesis of ICP and its expression may affected by the severity of ICP, and SOCS3 may a...

Melanocortin receptor-mediated effects on obesity are distributed over specif...

de Backer(M W A),la Fleur(S E),Brans(M A D... Int J Obes (Lond) 2011-08-10

...SOCS3) in the arcuate. Overexpression of AgRP in the Acc did not have any effect on the measured parameters.,Reduction o...

Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and ...

Rodrigues(Ananda Lages),de Moura(Egberto G... J Nutr Biochem 2011-04-25

...SOCS3 expression in adult animals, indicating central leptin resistance in adulthood. In conclusion, postnatal EO induce...

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