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The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte prolife...

Linke(Andreas),Goren(Itamar),Bösl(Michael ... J Invest Dermatol 2010-03-18

...SOCS3) overexpressing SOCS-3 in keratinocytes using the bovine keratin 5 promoter. Tsgn-K5/SOCS3 mice showed a constitut...

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcer...

Li(Yi),de Haar(Colin),Chen(Min),Deuring(Ja... Gut 2010-03-23

...SOCS3-positive cells in this progression reduced (LGD 33.3%; HGD 14.3%; UC-CRC 9.1%). In addition, methylation of the SO...

Regulation of multiple cytokine signalling pathways by SOCS3 is independent o...

Kiu(Hiu),Greenhalgh(Christopher J),Thaus(A... Growth Factors 2010-02-05

...SOCS3 protein degradation, by forming a molecular bridge to an E3 ubiquitin-ligase complex. Whether this regulation is r...

Time-resolved and tissue-specific systems analysis of the pathogenesis of ins...

Kleemann(Robert),van Erk(Marjan),Verschure... PLoS One 2010-05-20

...SOCS3. The alterations in skeletal muscle are largely opposite to those in liver and WAT.

Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch i...

You(Jia),Yu(Yue),Jiang(Lei),Li(Wenxia),Yu(... Mol Cell Biol 2010-04-09

...SOCS3, a key negative regulator of leptin signaling. Thus, these results unmask distinct binary roles for Try985-mediate...

Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes.

John(Thilo),Lodka(Dörte),Kohl(Benjamin),Er... J Orthop Res 2010-07-19

...SOCS3 expression in tenocytes was also induced by IL-6. The treatment of tenocytes with IL-6 and IL-10 had no effect on ...

Regional and temporal differences in leptin signaling in rat brain.

Burgos-Ramos(Emma),Chowen(Julie A),Argente... Gen Comp Endocrinol 2010-08-17

...SOCS3) in the hypothalamus, hippocampus, frontal cortex and cerebellum of adult male Wistar rats at 15min, 1 and 6h. The...

[Resistin inhibits rat insulinoma cell RINm5F proliferation].

Liu(Feng),Qiu(Jie),Zhang(Chun-Mei),Ji(Chen... Zhongguo Dang Dai Er Ke Za Zhi 2010-05-18

...SOCS3 mRNA levels were assessed by RT-PCR. The total Akt level and the phosphorylation status were assessed by Western b...

Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mou...

Zhao(J),Zhang(T),He(H),Xie(Y) Clin Exp Immunol 2010-07-09

...SOCS3 expression of CD4(+)T cells encounter allogeneic antigen in time. These results show that IL-2-induced high SOCS-3...

Deficient SOCS3 and SHP-1 expression in psoriatic T cells.

Eriksen(Karsten W),Woetmann(Anders),Skov(L... J Invest Dermatol 2010-06-15

...SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression o...

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