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SOCS3 expression induced by PIM2 requires PKC and PI3K signaling.

Narayana(Yeddula),Bansal(Kushagra),Sinha(A... Mol Immunol 2009-09-18

...SOCS3 expression. Further, pharmacological inhibition of ERK1/2, but not of p38 MAP kinase or JNK abrogated the induced ...

Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients ...

Vanni(Ester),Abate(Maria Lorena),Gentilcor... Hepatology 2009-09-18

...SOCS3; P < 0.05) and interleukin-18 (P < 0.05) expression.,Hepatitis C infection per se is associated with peripheral an...

TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 ...

Seifert(Anja),Taubert(Helge),Hombach-Kloni... Int J Oncol 2009-09-01

...SOCS3. Specificity of ERalpha-transactivation by ERK1/2 was confirmed by treatment with MAPKK-inhibitor PD98059. The com...

Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial ce...

Chatterjee(Prodyot K),Al-Abed(Yousef),Sher... Am J Physiol Cell Physiol 2009-11-17

...SOCS3 (suppressor of cytokine signaling; a regulator of the inflammatory activity of IL-6) in activated endothelial cell...

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin...

Taleb(Soraya),Romain(Mélissa),Ramkhelawon(... J Exp Med 2009-10-22

...SOCS3 in T cells reduces IL-17 and accelerates atherosclerosis. We also show that in human lesions, increased levels of ...

Enhanced activation of STAT pathways and overexpression of survivin confer re...

Zhou(Jianbiao),Bi(Chonglei),Janakakumara(J... Blood 2009-05-08

...SOCS3 in MV4-11-R cells. Hypermethylation of these SOCS genes leads to their transcriptional silencing. Survivin is dire...

Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses d...

Ortiz-Muñoz(Guadalupe),Martin-Ventura(Jose... Arterioscler Thromb Vasc Bi... 2009-04-02

...SOCS3 by vascular smooth muscle cells (VSMCs) and macrophages in the inflammatory region of the shoulders, when compared...

SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL...

Barclay(Johanna L),Anderson(Stephen T),Wat... Int J Cancer 2009-03-19

...SOCS3 expression in response to prolactin, a key mammotropic hormone. Quantitative real time PCR was used to examine SOC...

IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting.

Zhang(Liping),Du(Jie),Hu(Zhaoyong),Han(Guo... J Am Soc Nephrol 2009-03-26

...SOCS3 and decrease in IRS-1 compared with either rhIL-6 or SAA1 alone. We observed similar effects on SOCS3 and IRS-1 wh...

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis ...

Talbert(Matthew E),Langefeld(Carl D),Ziegl... Hum Genet 2009-03-26

...SOCS3 gene product participates in the feedback inhibition of a range of cytokine signals. Most notably, SOCS3 inhibits ...

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