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TGF-beta promotes Th17 cell development through inhibition of SOCS3.

Qin(Hongwei),Wang(Lanfang),Feng(Ting),Elso... J Immunol 2009-08-20

...SOCS3 promoter activity in T cells. Also, SOCS3 small interfering RNA knockdown partially compensates for the action of ...

Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by down...

Yu(Zu-Bin),Bai(Li),Qian(Pin),Xiao(Yin-Bin)... Cell Biol Int 2009-12-03

SOCS3 is regarded as a major negative regulator of STAT3. Recent evidence indicates that SOCS3 regulates strength and du...

Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in n...

Cho(Hyun Jin),Jin(Seok Min),Son(Sung Min),... Biochem Biophys Res Commun 2009-07-27

...SOCS3 overexpression, reduced levels of BACE1 promoter activity, expression of endogenous BACE1, and generation of Abeta...

Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-...

Chechlinska(Magdalena),Siwicki(Jan Konrad)... BMC Genomics 2009-07-24

...SOCS3, LIF and IL13 were down-regulated and RPS24, SQSTM1, TMEM1, LRRC8D, ECOP, YY1AP1, C1orf63, ASAH1, SLC25A46 and MIA...

Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on reg...

Park(Kevin K),Hu(Ying),Muhling(Jillian),Po... Mol Cell Neurosci 2009-09-22

...SOCS3 mRNA and decreased SOCS3 protein expression. CNTF injection also transiently increased retinal leukemia inhibitory...

Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 a...

Kim(Kyeongjin),Kim(Hye Young),Son(Eun Jeon... Cell Signal 2009-07-10

...SOCS3 in the presence of oleic acid. Finally, oleic acid impaired the insulin signaling cascades through inhibition of t...

Impact of host insulin resistance on fibrosis and response to interferon in c...

Moţa(Maria),Popa(Simona),Mota(E),Diaconesc... Rom J Intern Med 2009-04-23

...SOCS3), and hyperinsulinemia have been considered as heavily influencing fibrosis extension and nonresponsiveness to the...

Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischae...

Caraceni(P),Pertosa(A M),Giannone(F),Domen... Gut 2009-09-03

...SOCS3 gene expression by real-time polymerase chain reaction (RT-PCR). Systolic blood pressure and hepatic blood flow we...

Differential signaling of cmvIL-10 through common variants of the IL-10 recep...

Gruber(Sabine G),Gloria Luciani(Maria),Gru... Eur J Immunol 2009-02-11

...SOCS3 and signaling lymphocytic activation molecule mRNA expression. These data suggest that the IL-10R1 variants differ...

Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesan...

Isshiki(Keiji),He(Zhiheng),Maeno(Yasuhiro)... Kidney Int 2009-01-19

...SOCS3 did not affect IGF-1R signaling. Insulin directly increased STAT5 and SOCS2 expression in mesangial cells. This st...

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