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Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expres...

Song(Kyoung Seob),Kim(Kyubo),Chung(Kwang C... Biochem Biophys Res Commun 2008-12-15

...SOCS3 and NonO. A dominant-negative SOCS3 mutant (Y204F/Y221F) did not bind to NonO. Interestingly, SOCS3 overexpression...

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myelopr...

Fourouclas(Nasios),Li(Juan),Gilby(Daniel C... Haematologica 2008-11-18

...SOCS3 being a target gene of JAK2/STAT5 signaling. There was a trend towards an association between SOCS3 methylation an...

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imb...

Zhang(Xiaoqing),Zhang(Guo),Zhang(Hai),Kari... Cell 2008-10-30

...SOCS3, a core inhibitor of insulin and leptin signaling. Our results show that the hypothalamic IKKbeta/NF-kappaB progra...

Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia...

Capello(Daniela),Deambrogi(Clara),Rossi(Da... Br J Haematol 2008-07-03

...SOCS3, SOCS1 and PTPN6 in 112 CMPD and 20 acute myeloid leukaemia (AML) post-CMPD. SOCS3 methylation occurred at high fr...

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine sign...

Croom(Hayley A),Izon(David J),Chong(Mark M... Mol Immunol 2008-07-02

...SOCS3. Here, we find that both SOCS1 and SOCS3 are expressed during early thymopoiesis, with expression coincident durin...

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defecti...

Tanaka(Kentaro),Ichiyama(Kenji),Hashimoto(... J Immunol 2008-06-10

...SOCS3-overexpressed cells, indicating that suppression of Smads was independent of SOCS3. Therefore, SOCS1 is necessary ...

SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but ...

Yang(Tangbin),Stark(Patrik),Janik(Katrin),... J Immunol 2008-06-10

...SOCS3, and the role of SOCS1 during infection with C. pneumoniae in mice. Bone marrow-derived macrophages (BMM) and dend...

Substitution of pseudokinase domain residue Val-617 by large non-polar amino ...

Dusa(Alexandra),Staerk(Judith),Elliott(Joa... J Biol Chem 2008-06-17

...SOCS3), a mechanism by which JAK2 V617F overcomes inhibition by SOCS3. The V617W mutant induced a myeloproliferative dis...

SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healin...

Zhu(Bing-Mei),Ishida(Yuko),Robinson(Gertra... J Invest Dermatol 2008-06-24

...Socs3 and gp130 genes restored normal wound healing. Moreover, deletion of Socs3 only in keratinocytes caused impaired w...

Suppressors of cytokine-signaling proteins induce insulin resistance in the r...

Liu(Xuebin),Mameza(Marie G),Lee(Yun Sang),... Diabetes 2008-08-01

...SOCS3. We further show that the SOCS3 level is elevated in retina by oxidative stress, metabolic stress of insulin-defic...

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