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M2 macrophage-derived exosomes mitigate acute inflammation following ischemic s…

Song(J),Su(G),Chen(W),Xie(X),Zhang(Z) Front Neurol None

...Syk) and signal transducer and activator of transcription 3 (Stat3) in microglia, consequently reducing the production o...

Sibakazin: a novel black fly derived non-classical kazal protease inhibitor, ta…

Li(Z),He(Y),Shen(Y),He(M),Lin(T),Yang(J),Mu(… Insect Biochem Mol Biol 2026-04-00

...Syk/PLCγ2/Akt signaling cascade to block thrombus initiation, while simultaneously inhibiting the ADP receptor P2Y12, di...

Role of eCIRP in Mediating Post-ischemia Microglial Phagocytosis via TREM-2 Rec…

Li(P),Sun(Z),Chen(Y),Fang(Z),Yu(D),Wang(L),R… Mol Neurobiol 2026-03-04

...Syk-ERK1/2 signaling. Treatment with recombinant human CIRP (rhCIRP) further increased the expression of microglial acti...

Paeonol alleviates atherosclerosis by inhibiting CD8+ T-cell activation via tar…

Yang(Y),Zhang(T),Dong(L),Liu(Y),Wu(H),Shi(X)… J Ethnopharmacol 2026-05-23

...SYK, upregulated in atherosclerotic aortas, was directly targeted by Pae. Pae inhibited SYK phosphorylation; blocked NFA...

CD49d governs immune synapse formation through actin rearrangements and synchro…

Polcik(L),Pethe(A),Ashok(D),Tissino(E),Ferná… Blood 2026-06-25

...Syk and PLCɣ2 activation was found. Mechanistically, the CD49d-BCR interplay involved their colocalization, and CD49d co...

High-throughput fragment screening identifies a new small molecule scaffold tha…

Fuchs(N),El Gaamouch(F),Nada(H),Cho(S),Gabr(… Bioorg Med Chem 2026-06-00

...SYK and DAP12 in HEK cells as wells as on microglial phagocytosis in HMC3 cells. Additionally, an in silico analysis rev...

Bannakunin: a dual-target Kunitz inhibitor bridging anticoagulation (FXa/XIIa) …

He(M),He(Y),Feng(X),Li(Z),Lin(T),Yang(J),Luo… Cell Mol Biol Lett 2026-02-22

...Syk/PLCγ2 signalling pathway and the release of Ca2+, TXB2 and ATP. Furthermore, Bannakunin could effectively inhibit AD...

Sustained monocyte activation by persistent challenges with either oxLDL or fre…

Wu(Y),Geng(S),Atkinson(G),Caldwell(B),Wang(J… Immunohorizons 2026-02-12

...SYK-mTORC1-STAT3/5 signaling axis. Notably, the inflammatory state persisted even after stimulus withdrawal, suggesting ...

A biocompatible visible-light-crosslinkable dimethylglycine grafted gelatin hyd…

Zhao(M),Xia(S),Yun(L),Chen(X),Jian(X),Xu(F),… Int J Biol Macromol 2026-03-00

...Syk/NF-κB pathway. Consequently, M1 macrophage polarization is inhibited, creating a favorable osteoimmune microenvironm...

Assessing Aβ-independent effects of Module 42 on immune function in vitro.

Ajith(I),Bakshi(S),Mead(E),Gileadi(O),Katis(… Alzheimers Dement 2026-02-00

...Syk kinase activity. No M42 proteins had an effect on viability. Our results suggest an additional role for M42 in AD vi...

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