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Vav proteins are necessary for correct differentiation of mouse cecal and colon…

Liu(John Y),Seno(Hiroshi),Miletic(Ana V),Mil… J Cell Sci 2009-04-27

...Vav2(-/-);Vav3(-/-)) resulted in defective expansion of microtubule cytoskeletons, a significant decrease in cell height...

Rac GTPases play critical roles in early T-cell development.

Dumont(Celine),Corsoni-Tadrzak(Agnieszka),Ru… Blood 2009-05-08

...Vav2, and Vav3, which function as guanine nucleotide exchange factors for Rac1 and Rac2. These results show that a pathw...

Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic…

Yi(Fan),Xia(Min),Li(Ningjun),Zhang(Chun),Tan… Hypertension 2009-01-08

...Vav2 variant (onco-Vav2), we found that overexpression of Vav2 led to significant increases in Rac1 activity, superoxide...

A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 sig…

Bouquier(Nathalie),Vignal(Emmanuel),Charrass… Chem Biol 2009-09-10

...Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its abilit...

Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor gro…

Brantley-Sieders(Dana M),Zhuang(Guanglei),Va… Mol Cancer Res 2009-06-23

...Vav2/3 deficiency in endothelial cells. Vav2/3-deficient endothelial cells displayed reduced migration in response to tu...

RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia …

Elwell(Cherilyn A),Ceesay(Alhaji),Kim(Jung H… PLoS Pathog 2008-04-28

...Vav2, and two actin nucleators, WAVE2 and Cortactin. Finally, we show that TARP, a bacterial type III secreted actin nuc...

Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T ce…

Lee(Li-Fen),Lih(Chih-Jian),Huang(Chao-Jen),C… Proc Natl Acad Sci U S A 2008-08-19

...Vav2, Rho GTPase-activating protein, calcium channel voltage-dependent, L type alpha1C subunit (CaV1.2), IL-1 receptor-a...

Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.

Lane(B Josh),Mutchler(Charla),Al Khodor(Souh… PLoS Pathog 2008-04-28

...Vav2, in a phosphotyrosine-dependent manner. The tyrosine phosphorylation profile of the sequence YEPISTENIYESI within T...

Identification and functional analysis of phosphorylated tyrosine residues with…

Fang(Wei Bin),Brantley-Sieders(Dana M),Hwang… J Biol Chem 2008-07-15

...Vav2 and Vav3 guanine nucleotide exchange factors, whereas Tyr(P)(734) binds to the p85 regulatory subunit of phosphatid...

Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary end…

Birukova(Anna A),Zagranichnaya(Tatiana),Alek… J Cell Physiol 2008-04-29

...Vav2 and Rac-mediated EC barrier protective responses. Our results show that ANP stimulated protein kinase A and the Epa...

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