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Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dep...

Uotani(Shigeo),Abe(Takahiro),Yamaguchi(Yos... Biochem Biophys Res Commun 2006-12-22

...SOCS3 (inhibitor of JAK2) resulted in a marked reduction of AMPK activation in response to leptin. These findings sugges...

Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe a...

Horiuchi(Y),Bae(S-J),Katayama(I) Clin Exp Dermatol 2006-05-02

...SOCS3) may mediate Th2 regulatory response through negative regulation of Th1 pathways. We examined SOCS3 expression in ...

Mechanisms underlying the diminished sensitivity to prolactin negative feedba...

Anderson(Stephen T),Barclay(Johanna L),Fan... Endocrinology 2006-04-13

...SOCS3, mRNA expression was significantly (P < 0.01) up-regulated in suckled lactating rats. Semiquantitative RT-PCR on a...

Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition o...

Qasimi(Pooran),Ming-Lum(Andrew),Ghanipour(... J Biol Chem 2006-05-16

...SOCS3 protein important in mediating these effects, SOCS3-/- macrophages were reconstituted with SOCS3 mutated for the S...

IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts fro...

Gallucci(Randle M),Lee(Eric G),Tomasek(Jam... J Invest Dermatol 2006-03-30

...SOCS3 expression.

The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator...

Tups(A),Barrett(P),Ross(A W),Morgan(P J),K... J Neuroendocrinol 2006-04-26

...SOCS3) plays a critical role in the regulation of the seasonal body weight cycle. We analysed arcuate nucleus SOCS3 gene...

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hype...

Kinjyo(Ichiko),Inoue(Hiromasa),Hamano(Shin... J Exp Med 2006-05-30

...SOCS3 in T cells, we generated T cell-specific SOCS3 conditional knockout mice. We found that the mice lacking SOCS3 in ...

Leptin does not act directly on mammary epithelial cells in prepubertal dairy...

Thorn(S R),Purup(S),Cohick(W S),Vestergaar... J Dairy Sci 2006-07-13

...SOCS3) expression in these cells. Transcripts corresponding to the short leptin receptor form were present in mammary ti...

The structure of SOCS3 reveals the basis of the extended SH2 domain function ...

Babon(Jeffrey J),McManus(Edward J),Yao(She... Mol Cell 2006-05-22

SOCS3 is essential for regulating the extent, duration, and specificity of cellular responses to cytokines such as G-CSF...

Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

Calvisi(Diego F),Ladu(Sara),Gorden(Alexis)... Gastroenterology 2006-05-15

...SOCS3 promoters was observed only in a subclass of HCC with poor survival, suggesting that inactivation of these 2 genes...

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