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Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 an...

Rakshit(Diptendu S),Ly(Khanh),Sengupta(Tap... J Bone Joint Surg Am 2006-06-15

...SOCS3 (as well as pro-inflammatory mediators) was assessed with use of real-time reverse transcription-polymerase chain ...

Cytokine regulation in SARS coronavirus infection compared to other respirato...

Okabayashi(Tamaki),Kariwa(Hiroaki),Yokota(... J Med Virol 2006-05-26

...SOCS3) by SARS-CoV was significantly lower than that by RSV in spite of the significant production of IL-6. Toll-like re...

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inh...

Wormald(Samuel),Zhang(Jian-Guo),Krebs(Dani... J Biol Chem 2006-06-13

...SOCS3 therefore imposes bi-phasic kinetics upon IL-6 signaling. Compared with Socs3 mRNA, Socs1 mRNA was induced relativ...

Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunctio...

Resta-Lenert(Silvia),Barrett(Kim E) Gastroenterology 2006-04-06

...SOCS3 and STAT1,3.,Deleterious effects of TNF-alpha and IFN-gamma on epithelial function are prevented by probiotic, and...

Oncostatin M receptor-mediated signal transduction is negatively regulated by...

Stross(Claudia),Radtke(Simone),Clahsen(Tho... J Biol Chem 2006-05-23

...SOCS3 (suppressor of cytokine signaling 3). Binding of SOCS3 to the phosphorylated Tyr(759) in the cytoplasmic region of...

Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines,...

Kubo(Masato),Inoue(Hiromasa) Curr Allergy Asthma Rep 2006-07-28

...SOCS3 and SOCS5 are predominantly expressed in Th2 and Th1 cells, respectively, and they reciprocally inhibit the Th1 an...

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes...

Shi(Hang),Cave(Belinda),Inouye(Karen),Bjør... Diabetes 2006-04-19

...SOCS3 mouse) overexpressing SOCS3 in adipose tissue. Overexpression of SOCS3 in adipocytes decreases IRS1 protein levels...

Identification of blood biomarkers of rheumatoid arthritis by transcript prof...

Shou(Jianyong),Bull(Christopher M),Li(Li),... Arthritis Res Ther 2006-07-24

...Socs3, were identified and validated by quantitative TaqMan RT-PCR analysis using independent blood samples. Finally, im...

Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.

Takahashi(Yutaka),Dominici(Massimo),Swift(... J Biol Chem 2006-07-05

...SOCS3) is a negative regulator of cytokine signaling. Targeted disruption of SOCS3 revealed embryonic lethality on E12.5...

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/ST...

Tron(Kyrylo),Samoylenko(Anatoly),Musikowsk... J Hepatol 2006-11-14

...SOCS3) binding site within the gp130 IL-6 receptor subunit. Among the three putative STAT binding elements (SBE) in the ...

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