...TSC1/TSC2 expression, hypoxic status, expression of endoplasmic reticulum (ER) stress markers and calcium transport from...
...TSC1/2-mTOR and PI3K-Akt-mTOR pathways). In this complex scenario it is important to find prognostic and predictive fact...
...TSC1 or TSC2. Complex formed by the products of the TSC genes regulates cell growth and proliferation by inhibition of m...
...TSC1/TSC2 complex (TSC1/2) cause tuberous sclerosis (TSC), a hereditary syndrome with neurological symptoms and benign h...
...Tsc1) gene, an mTOR inhibitor, in the rods of the Pde6b preclinical RP mouse model and observed, functionally and morpho...
...Tsc1 or Pten caused mouse pituitary prolactinoma, which was abolished by rapamycin treatment. Mechanistically, the expre...
...Tsc1-deficient glioma cells than that by Tsc1-competent glioma cells, indicating a crucial function for mitochondrial bi...
...TSC1 mutations. In addition, luminal tumors were characterized by the overexpression of E-Cadherin, HER2/3, Rab-25, and ...
...TSC1 activity, which led to mTORC1 inhibition. AMPK-mediated raptor phosphorylation further reduced mTOR's kinase functi...
...TSC1. The knockout mice demonstrated testicular developmental defects, partial spermatogenic arrest, excessive germ cell...
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