...Tsc1, suppressed these fluxes. Only glycogen synthesis was impaired by both loss of insulin receptor and mTORC1 activati...
...TSC1 or TSC2 and a mosaic of psychological and cognitive defects. Tsc1 loss of heterozygosity contributes to severe dend...
...TSC1, and others, occur which form tumors in the urinary bladder. These genes play an important role in the regulation o...
...TSC1/TSC2 cause mosaic forms of PTEN hamartoma tumor syndrome or tuberous sclerosis complex, respectively. Distinct feat...
...TSC1 and HIF-2α in the progression of VHL altered tumors, implies the interplay between pVHL and TSC1.
...TSC1) or 2 (TSC2) gene.,In a 38-year-old Asian woman, two well-circumscribed nodules in the left lung and multiple thin-...
...TSC1 mutations. In addition, luminal tumors were characterized by the overexpression of E-Cadherin, HER2/3, Rab-25, and ...
...TSC1/Tsc1), suppresses mammalian/mechanistic target of rapamycin complex 1 (mTORC1), rapalogs have been used as therapeu...
...TSC1-/- fibroblasts exposed to low-dose genotoxins. This RS is characterized by elevated nucleotide incorporation rates ...
...TSC1/TSC2 and germline loss-of function mutations of these genes are established to cause PTEN Hamartoma Tumor Syndrome ...
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