...TSC1 or TSC2 genes, which encode proteins forming a complex that plays an important role in modulating mTOR activity. We...
...Tsc1) did not promote growth in anchorage-free conditions. Additionally, we generated stable AML12 and MCF10A clones wit...
...TSC1 gene knockout) in three different inbred strains with distinct genetic backgrounds. The potential complexity of gen...
...TSC1/2-Rheb) axes, pivotally regulates intracellular anabolism and catabolism. mTORC1 deregulation is associated with va...
...TSC1/TSC2 genes. First-line mTOR inhibitors are an effective treatment, but metastatic PEComas eventually develop drug r...
...TSC1, and TSC2) and CDC73 was performed in 66 available tumor tissues from 64 patients with PCa. Follow-up lasted up to ...
...TSC1 or TSC2 mutations that lead to constitutive mTORC1 activation and progressive respiratory failure. While rapamycin ...
...TSC1 and TSC2, we identified several under-discovered brain-tumor-related genes, including TP53, CIC, IDH1 and NOTCH1, t...
...TSC1, c.1460C>G: p.S487C). Function annotation further suggested potential associations of C5, CRYAB, PIWIL1, and TSC1 w...
...TSC1, RNF167, PBXIP1, LRRC49, KATNAL2, IGF2BP2) stratified patients into high/low-risk groups with distinct survival, mu...
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