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Leptin receptor signaling and the regulation of mammalian physiology.

Myers(Martin G) Recent Prog Horm Res 2004-04-29

...SOCS3), as well as important positive effectors of leptin action. The Jak2-dependent activation of the insulin receptor ...

Endurance training partially reverses dietary-induced leptin resistance in ro...

Steinberg(Gregory R),Smith(Angela C),Worma... Am J Physiol Endocrinol Met... 2004-02-12

...SOCS3 expression. Future studies should examine changes in the actual protein content of SOCS3 in muscle and establish w...

Distinct activities of suppressor of cytokine signaling (SOCS) proteins and i...

van de Geijn(Gert-Jan M),Gits(Judith),Touw... J Leukoc Biol 2004-08-03

...SOCS3 expression was further elevated, while SOCS1 levels remained constant. SOCS box deletion mutants of SOCS1 and SOCS...

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differ...

Okamura(Atsuo),Iwata(Nobuko),Nagata(Aki),T... Blood 2004-05-27

...SOCS3) was stabilized by its physical association with CKIepsilon. Such stabilization by CKIepsilon was also seen in IL-...

Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through ...

Kawaguchi(Takumi),Yoshida(Takafumi),Harada... Am J Pathol 2004-12-17

...SOCS3(-/-) mouse embryonic fibroblast cells. Furthermore, HCV core suppressed insulin-induced phosphorylation of p85 sub...

Development of hydrocephalus in mice lacking SOCS7.

Krebs(Danielle L),Metcalf(Donald),Merson(T... Proc Natl Acad Sci U S A 2004-12-09

...SOCS3, and CIS play an important role in the termination of cytokine and growth factor signaling. However, the biologica...

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.

Sutherland(Kate D),Lindeman(Geoffrey J),Ch... Oncogene 2004-11-16

...SOCS3 was not hypermethylated in either cancer type. Consistent with this data, SOCS1 and SOCS2 but not SOCS3 suppressed...

Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma.

Cho-Vega(J H),Rassidakis(G Z),Amin(H M),Ts... Leukemia 2004-12-02

...SOCS3) is highly expressed in anaplastic lymphoma kinase (ALK)+ anaplastic large cell lymphoma (ALCL) cell lines. As SOC...

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice w...

Howard(Jane K),Cave(Belinda J),Oksanen(Lau... Nat Med 2004-08-19

...Socs3 in energy balance in vivo we undertook studies in mice with heterozygous Socs3 deficiency (Socs3(+/-)). We report ...

Preparation and expression of biologically active prolactin and growth hormon...

Ben-Yair(Liora),Slaaby(Rita),Herman(Asael)... Protein Expr Purif 2003-03-12

...SOCS3, and SOCS6 were prepared in pECFP-C1 and pEYFP-C1 plasmids. The biological activities of SOCS1 and SOCS3 tagged at...

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