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Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by...

Hong(Feng),Jaruga(Barbara),Kim(Won Ho),Rad... J Clin Invest 2003-01-31

...SOCS3, but upregulation of STAT1 activation and STAT1-induced proapoptotic signals and exacerbation of liver injury. Tak...

Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3.

Kong(Fansheng),Guo(Xialing),Noel(J Greg),W... Shock 2003-04-03

...SOCS3 mRNA expression. Anti-SOCS3, anti-STAT3, and anti-phosphorylated STAT3 labeling in both postburn rat liver and iso...

Differential roles of SOCS family members in EpoR signal transduction.

Jegalian(Armin G),Wu(Hong) J Interferon Cytokine Res 2003-03-31

...SOCS3, and cytokine-inducible SH2-containing protein (CIS) in response to EPO stimulation appears to depend on Stat5 but...

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 s...

Lehmann(Ute),Schmitz(Jochen),Weissenbach(M... J Biol Chem 2003-02-10

...SOCS3 also acts through the tyrosine motif 759 of gp130. However, the relative contributions of SHP2 and SOCS3 to the re...

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation o...

Rui(Liangyou),Yuan(Minsheng),Frantz(Daniel... J Biol Chem 2003-01-17

...SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated degradation. S...

Enhanced macrophage responsiveness to lipopolysaccharide and CD40 stimulation...

Takakura(R),Kiyohara(T),Murayama(Y),Miyaza... Inflamm Res 2003-11-25

...SOCS3) mRNA was evaluated by real-time quantitative RT-PCR.,In the presence of LPS or anti-CD40 mAb, TNF-alpha and IL-12...

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hy...

Kaszubska(Wiweka),Falls(H Douglas),Schaefe... Mol Cell Endocrinol 2003-10-03

...SOCS3) and c-fos, genes that are acutely induced by leptin. Using gene microarray analysis, we confirmed that PTP1B redu...

Alterations in Janus kinase (JAK)-signal transducers and activators of transc...

Podewski(Edith K),Hilfiker-Kleiner(Denise)... Circulation 2003-02-28

...SOCS3: -49%, P<0.01). Tyrosine-phosphorylation status of gp130 was increased (+60%, P<0.05), whereas tyrosine-phosphoryl...

A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediat...

Matsumoto(Akira),Seki(Yoh-ichi),Watanabe(R... J Exp Med 2003-03-20

...SOCS3(+/-) mice enhanced CD28-mediated IL-2 production, clearly indicating the correlation between expression level of S...

Negative regulation of gp130 signalling mediated through tyrosine-757 is not ...

Fairlie(W Douglas),De Souza(David),Nicola(... Biochem J 2003-07-22

...SOCS3) and Src homology 2 domain-containing tyrosine phosphatase-2 (SHP2), are recruited to Y757 following receptor acti...

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