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Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the...

Eyckerman(S),Broekaert(D),Verhee(A),Vandek... FEBS Lett 2001-01-04

...SOCS3), a potential mediator of this leptin resistance is recruited into the activated murine leptin receptor complex. U...

A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by ...

Hanada(T),Yoshida(T),Kinjyo(I),Minoguchi(S... J Biol Chem 2001-12-07

...SOCS3) play an essential role in the negative regulation of cytokine signaling. We have found that transgenic (Tg) mice ...

SOCS proteins: negative regulators of cytokine signaling.

Krebs(D L),Hilton(D J) Stem Cells 2001-12-07

...socs3 has revealed that SOCS3 is an important regulator of fetal liver hematopoiesis. The biological role of other SOCS ...

Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice...

Bartlett(S E),Banks(G B),Reynolds(A J),Wat... J Neurosci Res 2001-08-02

...SOCS3) decreased although janus kinase 2 (JAK2) did not change in the rapsyn deficient muscles compared with litter mate...

Placental defects and embryonic lethality in mice lacking suppressor of cytok...

Roberts(A W),Robb(L),Rakar(S),Hartley(L),C... Proc Natl Acad Sci U S A 2001-08-30

...SOCS3) exhibited embryonic lethality with death occurring between days 11 and 13 of gestation. At this stage, SOCS3(-/-)...

Fatty acids inhibit leptin signalling in BRIN-BD11 insulinoma cells.

Briscoe(C P),Hanif(S),Arch(J R),Tadayyon(M... J Mol Endocrinol 2001-06-14

...SOCS3 (suppressors of cytokine signalling) or cytokine inducible sequence (CIS). These data demonstrate that FAs modulat...

The effect of burn injury on suppressors of cytokine signalling.

Ogle(C K),Kong(F),Guo(X),Wells(D A),Aosasa... Shock 2001-06-07

...SOCS3 compared with sham at 4 h, 24 h, and 10 days after thermal injury in the liver. SOCS3 protein was increased at 4 a...

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.

Bjorbak(C),Lavery(H J),Bates(S H),Olson(R ... J Biol Chem 2001-02-01

...SOCS3. Indeed, SOCS3 binds specifically to phosphorylated Tyr(985) of LRb, and SOCS3 fails to inhibit transcription by E...

Interleukin-9 (IL-9) induces cell growth arrest associated with sustained sig...

Demoulin(J B),Van Snick(J),Renauld(J C) Cell Growth Differ 2001-08-30

...SOCS3) reduced STAT activation by human IL-9 and prevented inhibition of growth but not of apoptosis. Using mutated IL-9...

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and inte...

Suzuki(A),Hanada(T),Mitsuyama(K),Yoshida(T... J Exp Med 2001-05-17

...SOCS3/SSI3), which play an essential role in the negative regulation of cytokine signaling. We have investigated the rol...

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